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NCT Number: NCT07095504

A Study of Cardiac Rehabilitation Intervention to Improve Cardiovascular Health and Outcomes

A single-group, multi-center, non-randomized clinical trial will be conducted to assess the feasibility of implementing an enhanced virtual world-based cardiac rehabilitation (VWCR) program within a muti-site clinical trial.

Active, Not Recruiting

This study is active but is not currently recruiting participants.

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Key information

Conditions

Cardiovascular Health

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

University of California (UCI), Irvine, Irvine, California, United States

Loading trial locations.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Indication for CR according to Centers for Medicare & Medicaid Services (CMS) guidelines (diagnosed within the preceding 12 months) to include one or more of the following:
  • Myocardial infarction
  • Coronary artery bypass surgery
  • Current stable angina (chest pain)
  • Heart valve repair or replacement
  • Percutaneous transluminal coronary angioplasty (PTCA) or coronary stenting
  • Heart or heart-lung transplant
  • Stable chronic heart failure
  • Receiving care at one of the participating CR centers
  • Age ≥18 years
  • Basic Internet navigation skills
  • Active email address
  • Access to Internet at home or public access (church, library, etc) for 3 virtual visits per week

Exclusion criteria

  • High risk patients according to the AACVPR risk stratification44 given safety concern of unsupervised exercise
  • Patients receiving continuous inotropic support
  • Recent receipt of a mechanical support device
  • Presence of hemodynamically unstable dysrhythmias (e.g., ventricular tachycardia)
  • Decompensated heart failure
  • Symptomatic valvular heart disease
  • Uncontrolled angina
  • Pregnancy (due to associated hormonal and weight changes) per patient report
  • Receiving continuous inotropic support
  • Presence of a mechanical circulatory support device
  • Decompensated heart failure
  • Symptomatic valvular heart disease
  • Uncontrolled angina
  • Presence of hemodynamically unstable dysrhythmias (e.g., ventricular tachycardia) given safety concern of unsupervised exercise
  • Visual/hearing impairment or mental disability that would preclude independent use of the VW platform
  • Non-English-speaking patients due to logistical challenges with real time translation over a virtual platform
  • Currently participating in a cardiac rehab program

Treatment and study plan

Virtual World-based Cardiac Rehabilitation (VWCR) program

Behavioral

24 Virtual World-based Cardiac Rehabilitation sessions over the course of 8 weeks (3 sessions/week). Weekly visits include 1:1 video visit with Exercise Physiologist, 1:1 video visit with Nurse Coach, and virtual group education session followed by social discussion.

Primary outcomes

  1. Change in Cardiovascular health score

    Time frame: Baseline, 2 Months, 5 Months

    Cardiovascular health score will be determined by the American Heart Association's (AHA) Life's Essential 8 (LS8). The scale is 0-100 pts (low to high), with LE8 categories as low (0-49), moderate (50-79) and high (80-100). A higher score indicates higher cardiovascular health.

  2. Percent of Virtual world-based cardiac rehabilitation attended

    Time frame: Baseline, 6 Months

    Virtual world-based cardiac rehabilitation attended will be determined by the number of sessions prescribed vs the number of sessions attended (reported as a percent).

Secondary outcomes

  1. Number of cardiovascular hospital readmissions

    Time frame: Baseline, 6 Months

    Cardiovascular Hospital readmissions will be determined by the number of times a patient is admitted to the hospital after initial admission.

  2. All-cause mortality

    Time frame: 6 Months

    All-cause mortality will be determined by the number of patient deaths no matter the cause.

Sponsors and collaborators

Lead sponsor

Mayo Clinic

Other

Registry information

Official study title

Destination Cardiac Rehab: A Multicenter Feasibility Clinical Trial of an Enhanced Virtual World-based Cardiac Rehabilitation Intervention to Improve Cardiovascular Health and Outcomes Among Cardiac Patients

Important dates

Study start
2025
Primary completion
2026
Study completion
2026
First posted
Jul 31, 2025
Registry last updated
Feb 27, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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