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NCT Number: NCT07572955

A Study Of Acute Decompensated Heart Failure

The purpose of this study is to examine shorter hospitalization length as well as a reduced rates of recurrent heart failure hospitalization compared to current standard of care in Acute Decompensated Heart Failure. A 1-day reduction in hospital length of stay in unblinded subjects receiving daily HF-FOCUS examinations compared to a blinded standard of care arm.

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Key information

Conditions

Acute Decompensated Heart Failure

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Mayo Clinic in Rochester

Rochester, Minnesota, 55905, United States

Location contact

Andy Dang

CONTACT

[email protected]

507-255-7752

Jared Bird, MD

PRINCIPAL_INVESTIGATOR

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Subjects ≥18 years of age
  • Admitted to St. Mary's Hospital Cardiology Progressive Care Unit (Cardiology 1-5 teams)
  • Admission diagnosis of either:
  • Acute systolic heart failure
  • Acute on chronic systolic heart failure
  • Acute diastolic heart failure
  • Acute on chronic diastolic heart failure
  • Acute right heart failure
  • Acute on chronic right heart failure
  • Failure heart biventricular
  • Able to provide informed consent and willing to undergo daily lung ultrasound examinations during their hospitalization.

Exclusion criteria

  • Subjects <18 years of age
  • Unable to provide informed consent.
  • Unwilling to undergo daily lung ultrasound examinations.

Treatment and study plan

Lung Ultrasound

Diagnostic Test

Patients will undergo lung ultrasound assessments at hospital admission, daily throughout admission, and at hospital discharge.

Primary outcomes

  1. Number of days in the hospital

    Time frame: Baseline

    The number of days a patient is in the hospital will be determined by the day of admission and day of discharge. The day of discharge will be defined as when the consultant physician states that the patient is medically ready for discharge from the hospital.

Secondary outcomes

  1. Number of re-hospitalized patients

    Time frame: Baseline

    Number of patients re-hospitalized will be determined by the number of patients admitted to the hospital post discharge

  2. Number of deaths

    Time frame: Baseline

    Number of deaths will be determined by number of patient deaths due to any cause

  3. Change in effective diuresis

    Time frame: Baseline, up to 90 Days

    Diuresis will be measured from a urine sample and calculated by total diuresis in liters/admission weight in kilograms

  4. Change in diuretic dosing

    Time frame: Baseline, up to 90 Days

    Diuretic dosing will be measured in mg

  5. Change in Lung Congestion

    Time frame: Baseline, up to 90 Days

    Lung congestion will be measured using a lung ultrasound and measured as a percentage

Study contacts

Contact information is provided by the study sponsor or research team.

Andy Dang

CONTACT

[email protected]

507-255-7752

Sponsors and collaborators

Lead sponsor

Mayo Clinic

Other

Registry information

Official study title

HF-FOCUS: Serial Lung Ultrasound And Peripheral Venous Pressure Monitoring To Enhance The Care Of Hospitalized Patients With Acute Decompensated Heart Failure

Important dates

Study start
2026
Primary completion
2028
Study completion
2028
First posted
May 7, 2026
Registry last updated
May 7, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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