A Study of [¹⁴C]-LY3023414 in Healthy Participants

Inclusion criteria

• Healthy men or women

• Male participants: Will be sterile (including vasectomy), confirmed by documentation. Men who are sexually active with a pregnant partner agree to use a condom for 91 days from the time of dosing
• Female participants: Women not of childbearing potential due to surgical sterilization (at least 6 months after hysterectomy with or without bilateral oophorectomy or at least 6 months after tubal ligation) confirmed by medical history or menopause. Postmenopausal women include women with spontaneous amenorrhea for at least 12 months, not induced by a medical condition such as anorexia nervosa and not taking medications during the amenorrhea that induced the amenorrhea (eg, oral contraceptives, hormones, gonadotropin releasing hormone, anti-estrogens, selective estrogen receptor modulators, or chemotherapy) and a follicle-stimulating hormone level greater than 40 milli international units per milliliter (mIU/mL)
• Have a body mass index (BMI) of 18.5 to 32.0 kilograms per meter square (kg/m²)
• Have clinical laboratory test results within normal reference range for the population or investigator site
• Have venous access sufficient to allow for blood sampling

Exclusion criteria

• Have participated in a [¹⁴C]-study within the last 6 months prior to admission for this study. The total 12-month exposure from this study and a maximum of one other previous [¹⁴C]-study within 6 to 12 months of this study must be within the Code of Federal Regulations (CFR) recommended levels considered safe: Less than 5000 millirem (mrem)/year whole body exposure.
• Exposure to significant diagnostic, therapeutic, or employment-related radiation within 12 months prior to dosing (eg, serial x-ray or computed tomography scans, barium meal, current employment in a job requiring radiation exposure monitoring)
• Are participants who have previously completed or withdrawn from this study or any other study investigating LY3023414, and have previously received the investigational product
• Have known allergies to LY3023414, related compounds, or any components of the formulation
• Regularly use known drugs of abuse and/or show positive findings on urinary drug testing
• Show evidence of human immunodeficiency virus (HIV) infection and/or positive human HIV antibodies
• Show evidence of hepatitis C and/or positive hepatitis C antibody
• Show evidence of hepatitis B and/or positive hepatitis B surface antigen
• Intend to use over-the-counter or prescription medication within 7 days prior to dosing
• Have donated blood of more than 500 milliliter (mL) within the last month
• Have an average weekly alcohol intake that exceeds 21 units per week, or are unwilling to stop alcohol consumption from 48 hours prior to admission and while resident in the Clinical Research Unit (CRU)
• Have consumed herbal supplements, grapefruits or grapefruit-containing products, Seville oranges or Seville orange-containing products, star fruit or star fruit-containing products within 7 days prior to dosing or intend to consume during the study
• Are unwilling to refrain from consuming xanthine-containing food and drink from 48 hours prior to admission until discharge from the CRU
• Have a defecation pattern less than once per day or acute constipation within 3 weeks prior to admission
• Have a history of clinically significant adverse drug reactions or "drug allergy" to more than 3 types of systemically administered medications