A Study for HSK47388 in Participants With Ulcerative Colitis

Inclusion criteria

• Written informed consent must be obtained
• Male or female, ≥18 years old and ≤75 years old
• Willing and able to comply with study-specific procedures and the requirements of study protocol.
• Diagnosis of ulcerative colitis (UC)
• Baseline modified Mayo score of 5 to 9 and the endoscopy subscore 2 to 3
• Demonstrated an inadequate response, loss of response, or failure to tolerate previous conventional therapy or advanced therapy.

Exclusion criteria

• Subjects have used treatments within the time frame specified in protocol prior to the baseline visit
• Diagnosis of indeterminate colitis, ischemic colitis, Crohn's colitis or clinical findings suggestive of Crohn's disease
• Participants with current or prior diagnosis of fulminant colitis and/or toxic megacolon
• Presence of a stoma
• Presence or history of a fistula
• Intra-abdominal or other major surgery performed within 12 weeks before baseline
• History of extensive colonic resection
• Subjects have laboratory values meeting the criteria in protocol
• Concurrent conditions and history of other diseases as described in protocol