A Single Dose Of GSK189075 Taken By Mouth Containing Small Amounts Of Radioactivity Studied In Healthy Male Volunteers

Inclusion criteria

• Are a healthy, non-smoking male.
• Are 30 to 55 years old, inclusive.
• Have a Body Mass Index (BMI) between 19-30 kg/m2, inclusive; and a body weight >110 lbs.
• Have a history of regular bowel movements (at least 4 times per week).
• Are willing and able to provide written informed consent before the start of any study-related procedures.

Exclusion criteria

• Have any significant laboratory abnormality or history of liver or kidney disease.
• Have any significant abnormality in your electrocardiograms (ECG) which are recordings of your heart rhythm.
• Have a current condition(s) that alters normal gastrointestinal (GI) function (such as constipation or removal of your gallbladder).
• Have an illness that requires treatment by a physician in the 30 days before screening or a fever and illness in the 5 days before dosing.
• Have blood pressure that is outside the normal range.
• Have a resting pulse rate that is outside the normal range.
• Have had surgery within 3 months before screening, unless approved by the GSK medical monitor.
• Have a drug allergy which the investigator feels would make it unsafe for you to participate in the study.
• Have a history of or current abuse of alcohol.
• Have a history of or current use of illicit drugs, or a positive drug screen.
• Have used tobacco products within 3 months prior to screening or have a positive cotinine test result.
• Are unable to refrain from foods or beverages containing coffee, tea, or chocolate for 72 hours before dosing with study drug and until 24 hours after dose.
• Have a positive test for human immunodeficiency virus (HIV) antibody or hepatitis B surface antigen or hepatitis C antibody.
• Have taken prescription or non-prescription drugs, including vitamins, herbal products, or plant-derived supplements (including St John's Wort) within 14 days (or less than 5 half-lives) before the first dose of study medication, unless approved by the GSK medical monitor
• Have participated in an investigational drug study within the 30 days before screening, or participated within the last 12 months in a study with another radio labeled drug product.
• Have a total radiation exposure from the previous 3-year period that is over 10 mSv (either from your work or through participation in other research studies). Clinical (therapeutic or diagnostic) exposure will not be included.
• Have donated blood (450 mL or more) within the previous 12 weeks.
• Are in an occupation which requires monitoring for radiation exposure, nuclear medicine procedures or have had excessive x-rays within the past 12 months.
• Are not able to follow the study directions.