A Single-Center, Randomized, Double-Masked, Placebo and Active Controlled, Dose-Ranging Evaluation of the Duration of Action of Brimonidine Tartrate Ophthalmic Solution in the Control of Ocular Redness Induced by Conjunctival Allergen Challenge (CAC)

Inclusion criteria

• Be at least 18 years of age;
• If female, cannot be not pregnant or nursing
• Have a positive skin test reaction to cat hair, cat dander, grasses, ragweed, dog dander, cockroach, dust mite, and/or trees within the past 24 months;
• Have a calculated best corrected visual acuity of 0.6 logMAR or better in each eye as measured using an ETDRS chart;

Exclusion criteria

• Have known contraindications or sensitivities to the use of any of the study medications(s) or their components;
• Have any ocular condition that, in the opinion of the investigator, could affect the subject's safety;
• Have a presence of active ocular infection;
• Use specified disallowed medications during the study or appropriate pre-study washout period;
• Have any significant illness;
• Have planned surgery (ocular or systemic) during the trial period or within 30 days after;
• Have used an investigational drug or device within 30 days of the study or be concurrently enrolled in another investigational drug or device study within 30 days of the study;
• Be a female who is currently pregnant or nursing.