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OpenTrials
Completed

NCT Number: NCT02615912

A Single-Center, Exploratory Study to Analyze the Dynamics of Skin Microflora Following Exposure to Surfactants

The purpose of this study is to understand the changes in skin microflora, skin barrier function, and skin biochemical constituents in response to direct contact with model surfactants used in personal care articles. The results from this study will provide insights into the complex interaction between the skin microbiome and the epidermis after exposure to surfactants.

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Key information

Conditions

Dermatitis Skin Diseases Skin and Connective Tissue Diseases

Age range

18 year–60 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Reliance Clinical Testing Service

Irving, Texas, 75062, United States

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Healthy Subjects with Fitzpatrick Skin Types I, II or III

Exclusion criteria

  • Subjects with visible skin disease, tattoos, skin condition, or abnormal skin color

Treatment and study plan

PEG-40 Hydrogenated Castor Oil (Tagat CH40, Evonik) 1.5%

Other

Lauryl glucoside (Plantacare® 1200UP, BASF) 1.5%

Other

Sorbitan palmitate (SPANTM 40 (powder), Croda) 1.5%

Other

Silwet* DA-63 (Momentive) 1.5%

Other

Sodium lauryl sulfate (Sigma Aldrich) 1.0%

Other

Water (control)

Other

Primary outcomes

  1. Type of microbes present on skin after exposure to various surfactants

    Time frame: 4 days

    Microbes will be identified by metagenomic sequencing

  2. Amount of microbes present on skin after exposure to various surfactants

    Time frame: 4 days

Sponsors and collaborators

Lead sponsor

Kimberly-Clark Corporation

Industry

Registry information

Important dates

Study start
2015
Primary completion
2015
Study completion
2016
First posted
Nov 26, 2015
Registry last updated
Sep 28, 2016

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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