A Single and Multiple-Ascending Dose Study of CRN01941 in Healthy Adult Volunteers

Inclusion criteria

• Male and female subjects 18 to 55 years of age, inclusive, at time of screening (Parts 1 and 2 only).
• Males and females subjects 65 to 85 years of age at screening (Part 3 only).
• Females must be non-pregnant and non-lactating, postmenopausal by history and confirmed by follicle stimulating hormone (FSH) >30 U/L at Screening, or surgically sterile.
• Male subjects must be surgically sterile or agree to use highly effective form of contraception when sexually active with a female partner of child bearing potential.
• Body mass index (BMI) of 18 to 32 kg/m2, inclusive at Screening.
• Willing to provide signed informed consent.

Exclusion criteria

• Any uncontrolled or active major systemic disease which makes study participation unsafe or could interfere with evaluation of the endpoints of the study.
• History or presence of malignancy within the past 5 years, not including treated basal cell carcinomas and in situ cervical neoplasia.
• Use of any investigational drug within the past 60 days.
• Have a medically significant abnormality observed during screening or admission.
• Use of any prior medication without approval of the investigator within 14 days prior to admission.
• Subjects with human immunodeficiency virus (HIV), hepatitis B or hepatitis C infections. Subjects with previous hepatitis C infection that is now cured may be eligible.
• History of or current alcohol or substance abuse in the past 12 months
• Any condition that in the opinion of the investigator would jeopardize the subject's appropriate participation in this Phase 1 study.