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NCT Number: NCT04355299

A Short-term Mixed Exercise for Sarcopenic Hospitalized Aged 80+ Years

Most previous clinical trials that addressed exercise for sarcopenic elderly subjects focused on community-dwelling older adults who were relatively healthy. There is a notable paucity of high-quality research investigating the effects and feasibility of exercise for hospitalized or institutionalized older people, who are generally frailer and more severe in functional impairment than those living in the community. Moreover, most reported exercise programs were of long-term duration, which typically lasted 3 to 6 months with two sessions per week. It remains unclear whether short-term exercise would be effective for treating sarcopenia. Therefore, the investigators aimed to assess the effectiveness of short-term exercise for treating sarcopenia in hospitalized older patients aged 80 years and over.

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Key information

Conditions

Sarcopenia Atrophy Muscular Atrophy Nervous System Diseases Neurologic Manifestations Neuromuscular Manifestations Pathological Conditions, Anatomical Pathological Conditions, Signs and Symptoms Signs and Symptoms

Age range

80 year–102 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • aged ≥80 years;
  • being able to ambulate (assistance was acceptable);
  • being able to communicate and collaborate with the physiotherapist;
  • with sarcopenia defined by the AWGS criteria ;

Exclusion criteria

  • terminal illness;
  • uncontrolled heart failure;
  • myocardial infarction within the past three months;
  • uncontrolled respiratory failure;
  • bone fractures within the past three months;
  • acute pulmonary embolism;
  • major surgery within the past three months;
  • uncontrolled arrhythmia;
  • refusal to participate in this study.

Treatment and study plan

Balance training

Behavioral

The training to improve balance is to work on the core muscle groups that help to maintain your posture.,and increase muscular strength.

Resistance training

Behavioral

Resistance training is a form of exercise that improves muscular strength and endurance. During a resistance training workout, you move your limbs against resistance provided by your body weight, gravity, bands, weighted bars or dumbbells.

Aerobic Exercise

Behavioral

Aerobic exercise is any activity that gets your blood pumping and large muscle groups working. It's also known as cardiovascular activity.

Usual Care

Behavioral

received usual care

Primary outcomes

  1. The change of activities of daily living from the baseline to the end of the 2-week intervention

    Time frame: 2 weeks

    Basic activities of daily living (BADL) assessed by Barthel Index. The total score for Barthel Index ranges from 0 (worst) to 100 (best) points.

Secondary outcomes

  1. The change of gait speed

    Time frame: 2 weeks

    Gait speed was measured using a 4-meter walking test.

  2. The change of handgrip strength

    Time frame: 2 weeks

    Handgrip strength was measured using a digital grip dynamometer

  3. The change of the score of Short Physical Performance Battery

    Time frame: 2 weeks

    The Short Physical Performance Battery (SPPB) is an objective assessment tool for evaluating lower extremity functioning in older persons. The total score for SPPB ranges from 0 (worst) to 12 (best) points.

  4. The change of the score of Timed Up and Go test

    Time frame: 2 weeks

    The Timed Up and Go test (TUG) is a simple test used to measure basic functional mobility and safety with mobility. The score for the TUG is the time consumption of the whole process. The longer time consuption indicates the more worse outcome.

Sponsors and collaborators

Lead sponsor

Yuxiang Liang

Other

Registry information

Official study title

Effectiveness of a Short-term Mixed Exercise Program for Treating Sarcopenia in Hospitalized Patients Aged 80 Years and Older

Important dates

Study start
2016
Primary completion
2019
Study completion
2020
First posted
Apr 21, 2020
Registry last updated
Apr 22, 2020

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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