A Safety and Tolerability Study of ABT-126 in Elderly

The objectives of this study are to assess the safety, tolerability and pharmacokinetics of ABT-126 in elderly subjects.

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Key information

Conditions

Alzheimer's Disease Alzheimer Disease Brain Diseases Central Nervous System Diseases Dementia Mental Disorders Nervous System Diseases Neurocognitive Disorders Neurodegenerative Diseases Tauopathies

Age range

65 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Phase 1

Primary location

Site Reference ID/Investigator# 17283

Orlando, Florida, 32809, United States

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Healthy male or female subjects 65 years or greater.
Has a MMSE score of 27 or higher.

Exclusion criteria

History of dementia including by not limited to Alzheimer's disease, Parkinson's disease and mult-infarct dementia.
History of any significant neurological disease.
Has an estimated creatinine clearance < 30 mL/min

Treatment and study plan

ABT-126

Drug

See arm for details

Primary outcomes

Safety and Tolerability Assessments (i.e., ECG, clinical laboratory tests, vital signs, weight, AE assessment, physical and brief neurological examinations)

Time frame: Study Days -1 thru Day 28
Assess the Pharmacokinetics

Time frame: Study Days -1 thru Day 28

Sponsors and collaborators

Lead sponsor

Abbott

Industry

Registry information

Official study title

A Multiple Dose Study of Safety, Tolerability and Pharmacokinetics of ABT-126 in Elderly Subjects

Important dates

Study start: 2009
Primary completion: 2009
First posted: Mar 23, 2009
Registry last updated: Nov 2, 2010

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed