A Retrospective Cohort Study of Patient… | Clinical Trial

Key information

Conditions

Oesophageal Squamous Cell Carcinoma Carcinoma Carcinoma, Squamous Cell Digestive System Diseases Digestive System Neoplasms Esophageal Diseases Esophageal Neoplasms Esophageal Squamous Cell Carcinoma Gastrointestinal Diseases Gastrointestinal Neoplasms Head and Neck Neoplasms Neoplasms Neoplasms by Histologic Type Neoplasms by Site Neoplasms, Glandular and Epithelial Neoplasms, Squamous Cell

Sex eligibility

All sexes

Study type

Observational

About this study

This retrospective cohort study was conducted using the Registry for Thoracic Cancer Surgery at Samsung Medical Center (Seoul, South Korea), which has included all patients who underwent thoracic surgery

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Patients who underwent curative surgery for esophageal cancer

Exclusion criteria

cervical esophageal cancer
gastroesophageal junction cancer
histology other than squamous cell carcinoma
patients with Child-Pugh class B or C liver cirrhosis

Treatment and study plan

Primary outcomes

Postoperative complications

Time frame: within 90 days after surgery

Complications related to fluid imbalance and portal hypertension, such as ascites, pleural effusion, and chyle leak; complications associated with impaired renal or hematologic function, including acute kidney injury, bleeding, and graft failure; and complications reflecting immune dysfunction and infection susceptibility, including pneumonia and empyema. Complications associated with impaired tissue healing, such as anastomotic leakage, were also analyzed. Liver failure and acute respiratory distress syndrome were considered separately. All complications were defined according to the Esophageal Complications Consensus Group, and their severity was assessed according to the Clavien-Dindo classification.

Secondary outcomes

Overall survival

Time frame: 10 years after surgery

Interval from the date of surgery to death or censoring

Sponsors and collaborators

Lead sponsor

Samsung Medical Center

Other

Registry information

Important dates

Study start: 1994
Primary completion: 2025
Study completion: 2025
First posted: Oct 1, 2025
Registry last updated: Oct 1, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed