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Completed

NCT Number: NCT04469543

A Retrospective Cohort Study: Influence of MTHFR C677T and A1298C Polymorphisms on the Survival of Pediatric Patients With Non-Hodgkin's Lymphoma

The primary purpose of this retrospective study was to investigate the influence of methylenetetrahydrofolate reductase (MTHFR) C677T/A1298C polymorphism on the survival of pediatric patients with Non-Hodgkin lymphoma (NHL) treated with modified NHL-BFM95 protocol in south China.

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Key information

Conditions

Pediatric Non-Hodgkin Lymphoma

Age range

Up to 18 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Sun Yat-Sen University Cancer Center

Guangzhou, Guangdong, 510060, China

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • aged ≤ 18 years;
  • newly diagnosed as the four main categories of NHL(Burkitt's lymphoma, lymphoblastic lymphoma, anaplastic large cell lymphoma, and diffuse large B-cell lymphoma) between 2014 and 2020;
  • treated according to the modified BFM95 protocol.

Exclusion criteria

  • aged > 18 years;
  • not newly diagnosed as the four main categories of NHL between 2014 and 2020;
  • treated according to chemotherapeutic regimens except for the modified BFM95 protocol.

Treatment and study plan

Primary outcomes

  1. Death

    Time frame: About six years

    Overall survival time was calculated from the time of initial diagnosis to death

  2. Events including progression, relapse, and secondary cancer

    Time frame: About six years

    Event-free survival (EFS) time was calculated from the time of initial diagnosis to first event.

Sponsors and collaborators

Lead sponsor

Sun Yat-sen University

Other

Registry information

Important dates

Study start
2014
Primary completion
2020
Study completion
2020
First posted
Jul 14, 2020
Registry last updated
Jul 14, 2020

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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