Skip to main content
OpenTrials
Recruiting

NCT Number: NCT04839003

A Registry of AL Amyloidosis (ReAL)

The purpose of this protocol is to generate a large registry of patients with AL amyloidosis.

Recruiting

Interested in participating?

Request Info

Key information

Age range

18 year–99 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Fondazione IRCCS Policlinico San Matteo

Pavia, 27100, Italy

Location status: Recruiting

Location contact

Giovanni Palladini, MD

CONTACT

[email protected]

+390382502994

About this study

Thanks to this registry, it will be possible to collect data at diagnosis and during follow up, in order to be able to describe the natural history of AL amyloidosis in a real-world setting and to define and validate prognostic models, response and relapse criteria applicable at any point of the disease.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • diagnosis of systemic AL amyloidosis;
  • treatment-naïve (pre-treatment data collected at participating center available for retrospective part);
  • age ≥18 years;
  • ability to understand and willingness to sign an informed consent (patients who already sign informed consent for clinical data to be used in retrospective analyses will be accepted);
  • planned (or ongoing) follow-up at participating center.

Exclusion criteria

  • non-AL amyloidosis;
  • previous treatment for AL amyloidosis.

Treatment and study plan

Primary outcomes

  1. Creation of a registry of patients with AL amyloidosis

    Time frame: 5 years

Sponsors and collaborators

Lead sponsor

Fondazione IRCCS Policlinico San Matteo di Pavia

Other

Registry information

Official study title

A Registry to Investigate Real-world Natural History, Impact of Therapies and Patterns of Progression of AL Amyloidosis (ReAL)

Acronym: ReAL

Important dates

Study start
2020
Primary completion
2027
Study completion
2027
First posted
Apr 9, 2021
Registry last updated
Apr 16, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.