NCT Number: NCT03802981
A Registry for Patients With Multifocal Ground Glass Opacities (GGOs)
The purpose of this registry study is to actively monitor people with GGOs and collect information about them, so that investigators can learn more about these lesions and about the risk of developing lung cancer in study participants whose GGOs are being monitored in the active surveillance program.
This study is active but is not currently recruiting participants.
Notify MeKey information
Conditions
Age range
19 year and older
Sex eligibility
All sexes
Study type
Observational
Primary location
McMaster University (Data Collection Only), Hamilton, Ontario, Canada
Who can participate
Healthy volunteers accepted: No
Only the study team can determine whether someone qualifies for participation.
Inclusion criteria
- Age greater than 18 years
- Have two or more GGOs on initial CT imaging
- GGOs must be measure ≤3.0 cm and ≥0.6 cm in the greatest dimension
- GGOs must be greater than half ground glass
A biopsy is not necessary for inclusion in the trial. Biopsy of a GGO, even with a diagnosis of adenocarcinoma, does not necessarily preclude enrollment in this surveillance protocol. In other words, patients with a diagnosis of adenocarcinoma are still eligible, at the discretion of the clinician and/or investigator, if they meet the above criteria.
Exclusion criteria
- Patients who are actively undergoing lung cancer treatment or have a history of lung cancer, except for cases of completely resected pathologic stage IA nonsmall cell lung cancer (NSCLC). Patients with stage IA NSCLC and multiple GGOs can enroll in this active surveillance protocol after complete resection of the NSCLC and confirmation of stage on final pathologic assessment.
- The presence of any solid lesion ≥0.6 cm suspicious for malignancy.
- Patients who are actively undergoing treatment for other malignancies
Treatment and study plan
Primary outcomes
-
lung cancer-specific survival
Time frame: 5 years
Sponsors and collaborators
Lead sponsor
Memorial Sloan Kettering Cancer Center
Other
Collaborators
- Brigham and Women's Hospital
- Duke University
- M.D. Anderson Cancer Center
- Mayo Clinic
- University of Pittsburgh
- University of Toronto
- Université de Montréal
- Washington University School of Medicine
Registry information
Official study title
Thoracic Surgery Oncology Group (TSOG) Protocol: Registry Trial of Active Surveillance for Multifocal Ground Glass Opacities (GGOs)
Important dates
- Study start
- 2019
- Primary completion
- 2027
- Study completion
- 2027
- First posted
- Jan 14, 2019
- Registry last updated
- Feb 18, 2026
OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.
View the official ClinicalTrials.gov record (opens in a new tab)This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.