A Real-world Study to Evaluate the Effectiveness of Intravascular Lithotripsy in Moderate to Severe Calcification Lesion of Lower Extremity Femoropopliteal Artery

Inclusion criteria

• Patients older than 18 years
• Rutherford scale: Grades 2-5.
• Moderate-severe calcification of lower extremity arteries (defined as calcification on both sides of the arteries, the length of the lesion greater than 5cm).
• The stenosis degree of the lesions was more than 70% confirmed by DSA, including chronic occlusive lesions.
• At least one sub-knee branch artery is patent (defined as a run-off score of 1 or less). • In-stent restenosis or restenosis with moderate to severe calcification.
• The stenosis degree of inflow blood vessel on the diseased side is less than 30% or the residual stenosis is less than 30% after first-stage treatment.
• Calcification lesions with thrombus can also be included in the group after the thrombus is completely cleared.
• Sign relevant informed consent.

Exclusion criteria

• Active infection of the affected limb.
• Patients with severe ischemia of the affected limb who are expected to undergo major amputation.
• The target blood vessels were artificial blood vessels or autologous vessels.
• Simple thrombosis lesion.
• Thromboangiitis obliterans, arteritis or connective tissue disease-based lesions.
• Inflow vessel stenosis is greater than 30% or residual stenosis is still greater than 30% after primary treatment.
• Allergic to contrast agent, heparin, anti-platelet therapy.
• Patients who are pregnant or lactating.
• Patients with cardiovascular and cerebrovascular events such as stroke or myocardial infarction within 3 months prior to enrollment.
• Patients who are currently in an ongoing interventional clinical study program.
• Patients who refuse to sign informed consent. •
• Patients who refuse to cooperate with long-term follow-up after surgery or who, for personal reasons, have difficulty communicating for quality of life assessment.