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OpenTrials
Completed

NCT Number: NCT02104934

A Randomised Controlled Trial Comparing Single Shot Adductor Canal Block With Local Infiltration Analgesia for Postoperative Analgesia After Total Knee Arthroplasty

Total knee arthroplasty or replacement (TKA), a commonly performed surgery for osteoarthritis of the knee, is a painful procedure and requires a multimodal analgesic approach. A method for analgesia is local infiltration analgesia (LIA), where a mixture of drugs is injected around the knee joint.

Adductor canal block (ACB) is an alternative regional anaesthesia technique which has been shown to result in minimal thigh weakness.

The investigators aim to study if the analgesia provided by ACB is superior to LIA while preserving quadriceps strength.

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Key information

Conditions

Analgesia in Total Knee Arthroplasty

Age range

45 year–85 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Changi General Hospital

Singapore

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Patients scheduled for primary TKA under single shot spinal anaesthesia, between ages 45-85 years old, American Society of Anesthesiologists (ASA) physical status 1 to 3 and BMI 18-35 kg/m2

Exclusion criteria

  • Patients unable to give consent, inability to communicate/ cooperate, patients with regular consumption of strong opioids (morphine, oxycodone) or steroids, allergy to local anaesthetics or any drugs included in the study, patients with lower limb surgery in the preceding year, patients with pre-existing neurological deficits and patients who have contraindications for spinal anaesthesia.

Treatment and study plan

Adductor canal block

Procedure

Primary outcomes

  1. Morphine consumption in the first 24 hours

    Time frame: 24 hours

    morphine consumption in the first 24 hours (including morphine administered in recovery and via PCA).

Secondary outcomes

  1. Pain Scores

    Time frame: 1, 6, 12, 24 hours; up to 48 hours postoperative

    Pain scores are recorded at 1, 6, 12, 24 and 48 hours post-operatively, assessed using a visual analog scale (0-100mm) at rest and during 45 degree passive flexion of knee.

  2. Morphine Consumption

    Time frame: At 48 hours

    The balance usage after primary outcome

  3. Postoperative Nausea and Vomiting

    Time frame: Up to 48 hours

    Presence/absence of nausea and vomiting, and total number of episodes of vomiting

  4. Sedation Scores

    Time frame: Up to 48 hours

  5. Quadriceps Strength

    Time frame: at 24 and 48 hours

Other outcomes

  1. Presence of Complications

    Time frame: up to 48 hours

    Hematoma, wound infection, neurological deficits, any incidence of fall

  2. Length of Hospital Stay

    Time frame: Up to 30 days

    Number of days till discharge

Sponsors and collaborators

Lead sponsor

Changi General Hospital

Other

Registry information

Important dates

Study start
2014
Primary completion
2015
Study completion
2016
First posted
Apr 7, 2014
Registry last updated
Apr 25, 2017

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.