A Prospective Study of Physical Function in Adults Who Receive Systemic Therapy for Stage I-III Gastroesophageal Cancer, FAST-GO Study

PRIMARY OBJECTIVE:

I. To determine the change in physical function from baseline to 6 months of treatment, as measured by the short physical performance battery (SPPB).

OUTLINE: This is an observational study.

Patients undergo blood sample collection as well as complete surveys, physical function tests and may complete an interview on study.

Inclusion criteria

• * Adults ≥ 18 years old at the start of study treatment.

• New diagnosis of early-stage (Stage I, II, III) esophageal, gastroesophageal junction, or gastric adenocarcinoma, squamous cell carcinoma, or poorly differentiated carcinoma.
• Plan to start systemic therapy for resectable or potentially resectable disease.
• Ability to understand and the willingness to sign a written informed consent document.

Exclusion criteria

• * Patients with stage I disease with plans to undergo endoscopic resection or surgery alone without perioperative systemic therapy.

• Metastatic disease at the time of diagnosis.
• Patients who are unable to provide informed consent.
• Any condition that would, in the Investigator's judgment, contraindicate the patient's participation in the clinical study due to safety concerns with clinical study procedures.
• Currently participating in another intervention research study seeking to improve functional status, alleviate frailty, increase muscle strength, or improve cognitive function.