A Prospective Randomized Trial on Mycophenolate Mofetil in Risk Penetrating Keratoplasty

The purpose of this prospectively randomized multicentre study was to prove the efficacy and safety of mycophenolate mofetil (MMF) to preventing graft rejection and improvement of clear graft survival following high-risk keratoplasty.

The patients of the MMF group receive MMF orally 2x1 g daily for 6 months. Endpoints were immune reaction free and clear graft survival and the occurence of side-effects.

Completed

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Key information

Conditions

Corneal Transplantation

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Phase 4

Primary location

University Eye hospital

Freiburg im Breisgau, 79106, Germany

Who can participate

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Keratoplasty with increased risk for immunologic graft rejection in the abscence of other risk factors for graft failure. (repeat keratoplasty, steroid-response, limbo-keratoplasty, oversized graft.

Exclusion criteria

Normal risk cases. Herpes-Keratitis. Glaucoma. Limbus stem cell deficiency.

Treatment and study plan

Mycophenolate Mofetil 2x 1g

Drug

Sponsors and collaborators

Lead sponsor

University Hospital Freiburg

Other

Collaborators

Hoffmann-La Roche

Registry information

Important dates

First posted: Dec 14, 2006
Registry last updated: Dec 15, 2006

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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Completed