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OpenTrials
Enrolling by Invitation

NCT Number: NCT07239167

A Prospective Cohort Study on Patient With Obesity Undergoing Weight Change

This prospective cohort study collected baseline data and followed up obese patients at their first visit to a weight loss clinic. The study examined the impact of various predictors and biomarkers on weight loss outcomes, aiming to establish an evidence-based foundation for personalized weight loss treatment.

Participants underwent a battery of measurements and questionnaires, including height, weight, waist circumference, blood pressure, blood tests, and questionnaires addressing diet, exercise, stress, sleep, measure handgrip strength ,and psychological well-being.

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Key information

Conditions

Obesity & Overweight Body Weight Body Weight Changes Glucose Metabolism Disorders Hyperinsulinism Insulin Resistance Metabolic Diseases Metabolic Dysfunction-Associated Steatohepatitis Metabolic Syndrome Nutrition Disorders Nutritional and Metabolic Diseases Obesity Obesity (Disorder) Overnutrition Overweight Pathological Conditions, Signs and Symptoms Signs and Symptoms Weight Loss

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

No.7, Chung Shan S. Rd.（Zhongshan S. Rd.）

Taipei, Zhongzheng Dist, 100, Taiwan

Who can participate

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Adults aged 18 years or older, regardless of gender.
  • Body mass index (BMI) ≥ 27 kg/m², or ≥ 24 kg/m² with one or more obesity-related comorbidities.
  • Willing to undergo any form of weight loss intervention.
  • Able to read and understand Chinese, willing to complete questionnaires, blood tests, and follow-up follow-up.
  • Voluntarily consent to participate and be willing to complete the subject consent form.

Exclusion criteria

  • Pregnant or breastfeeding women.
  • Individuals with significant mental illness (e.g., schizophrenia, severe depression) or cognitive impairment that may affect their ability to consent or cooperate with the study.
  • Individuals with severe organ dysfunction (e.g., end-stage renal disease, cirrhosis, congestive heart failure, etc.).
  • Individuals taking medications that significantly affect their weight (e.g., long-term steroids or antipsychotics) and cannot be discontinued.
  • Individuals deemed unsuitable for participation in this study by the study leader (e.g., individuals who are expected to be unable to complete follow-up).

Treatment and study plan

Primary outcomes

  1. Baseline data were collected and followed up during the subjects' initial visit to the weight loss clinic to establish an evidence-based basis for personalized weight reduction treatment.

    Time frame: Weight changes of subjects after 24 weeks, 48 weeks, 72 weeks, and 96 weeks.

Sponsors and collaborators

Lead sponsor

National Taiwan University Hospital

Other

Registry information

Important dates

Study start
2025
Primary completion
2027
Study completion
2035
First posted
Nov 20, 2025
Registry last updated
Mar 30, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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