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Completed

NCT Number: NCT05276661

A Project to Study Probiotic Beauty Products on Skin Improvement

The aim of the study was to use probiotic beauty products for 4 weeks and evaluate the impact of products on healthy skin.

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Key information

Conditions

Skin Diseases Skin and Connective Tissue Diseases

Age range

20 year–65 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Chia Nan University of Pharmacy ＆ Science

Tainan, 71710, Taiwan

About this study

Twenty subjects were recruited and informed to apply the lotion gel twice per day (3~5 mg/cm2 once) for 4 weeks. Two kinds of facial lotiongels, "A" gel and "B" gel, were provided to every subject. The "A" gel (TAC/Collagen lotiongel) was applied on subjects' right face and the "B" gel (placebo lotion) on their left face (formula showed as Table S2). Ordinary cosmetics usage was permitted but any change of usage was not allowed during the intervention. Outdoor activities (sun exposure) and the usage of sunscreen lotion were not limited in this study. Every subject was required to inspect his/her skin condition on week 0 and 4. Before inspection, the face was washed with water and waited for 30 min in an air-conditioned room (25°C, humility 55 ± 5%). Among these 20 subjects, eight of them had severe acne with at least two acne lesions on each side of face when participating this trial. They were instructed for more visits to evaluate the symptom of acne on week 1 and 2.

Skin hydration (Corneometer CM825, Courage + Khazaka Electroni, Germany), sebum (Callegari 1930, Italy), and inflammation detection (Chroma Meter MM-500, Minolta, Japan) of upper cheek were measured in every subject. The improvement in inflammation was positively correlated with a decrease of a* value or an increase of L* value. VISIA® Complexion Analysis (VISIA® Complexion Analysis, U.S.A.) was also employed to measure the skin inflammation, porphyrins numbers and brown spot numbers of whole face. The result was presented as the mean value and the relative percentage (%) to the baseline.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Healthy volunteers aged above 20 years old

Exclusion criteria

  • Subject with diseases of the skin, heart, liver, kidney, endocrine and other organs and patients with mental illness (according to medical history).
  • Subjects who have known cosmetic, drug or food allergies, difficulty in digestive tract absorption or disorder.
  • Female who is pregnant or nursing or planning to become pregnant during the course of the study.
  • Received facial laser therapy, chemical peeling or UV overexposure in the past 4 weeks.
  • Involuntary subject
  • People who is taking chronic disease medication

Treatment and study plan

TAC/Collagen gel

Dietary Supplement

Apply it twice per day for 4 weeks

placebo lotion

Dietary Supplement

Apply it twice per day for 4 weeks

Primary outcomes

  1. Effects of the TAC/Collagen Gel on Human Skin Hydration

    Time frame: Subjects will be tested in the 4th week

    Corneometer® CM825 was utilized to measure skin moisture. Units: arbitrary Corneometer® units 0-120

  2. Effects of the TAC/Collagen Gel on Human Skin Sebum

    Time frame: Subjects will be tested in the 4th week

    Callegari 1930 was utilized to measure skin inflammation. Units: arbitrary units.

  3. Effects of the TAC/Collagen gel on Human Skin Inflammation

    Time frame: Subjects will be tested in the 4th week

    Chroma Meter MM-500 was utilized to measure skin inflammation. Units: arbitrary units.

  4. Effect of TAC/Collagen Gel on Human Acne Healing and Porphyrins Numbers

    Time frame: Subjects will be tested in the 4th week

    VISIA Complexion Analysis System was utilized to measure skin texture. Units: arbitrary units

  5. Effects of the TAC/Collagen Gel on Human Skin Brown Spot Numbers

    Time frame: Subjects will be tested in the 4th week

    VISIA Complexion Analysis System was utilized to measure skin texture. Units: arbitrary units

Sponsors and collaborators

Lead sponsor

Chia Nan University of Pharmacy ＆ Science

Other

Collaborators

  • Glac Biotech Co., Ltd

Registry information

Official study title

Chia Nan University of Pharmacy & Science

Important dates

Study start
2020
Primary completion
2020
Study completion
2020
First posted
Mar 11, 2022
Registry last updated
Mar 11, 2022

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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