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NCT Number: NCT03234179

A Prognosis and Predicting Genetic Study of Lung Cancer

Lung cancer is a leading cause of cancer mortality among adults worldwide. The incidence rates of lung cancer among never smoking females in some parts of East Asia are among the highest in the world. The adenocarcinoma of lung being the most frequently identified histological type is more weakly associated with smoking, and often occurs in females and never-smokers. Although family history of lung cancer has been associated with histological subtypes, the inherited susceptibility factors that affect specific histology are unknown.

Genetic factors that determine individual predisposition to lung cancer have been identified via genome-wide association studies. These known common loci, however, explain only a small fraction of the familial risk of lung cancer. The hypothesis of this study is that there are genetic factors that confer inherited susceptibility among patients with primary non-small-cell lung cancer (NSCLC).

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Key information

Conditions

Lung Cancer Bronchial Neoplasms Carcinoma, Bronchogenic Carcinoma, Non-Small-Cell Lung Disease Attributes Disease Susceptibility Genetic Predisposition to Disease Lung Diseases Lung Neoplasms Neoplasms Neoplasms by Site Pathologic Processes Pathological Conditions, Signs and Symptoms Respiratory Tract Diseases Respiratory Tract Neoplasms Thoracic Neoplasms

Age range

20 year and older

Sex eligibility

All sexes

Study type

Observational

About this study

To delineate the genetic etiology underlying NSCLC, this study proposes to employ a family-based linkage analysis, together with rich data generated from NGS, to search for disease susceptibility locus for the patients with strong family history of primary NSCLC. By using family pedigrees, linkage analysis will be able to find co-segregation of alleles through multiple generations at a genetic susceptibility locus and a known genetic marker, and then the highly penetrate gene loci may be detected by our study. These gene loci will be a good genetic predictor of NSCLC which should be a great advantage in treatment, prevention and screening of NSCLC in the future.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • The patient's family (within third-degree relatives) has at least one diagnosed of primary non-small cell lung cancer.
  • The patient was diagnosed of primary non-small cell lung cancer at the age < 45 years old.

Exclusion criteria

  • Patients without the diagnosis of primary non-small cell lung cancer.
  • Patients who are combined with other malignancy and ongoing chemotherapy / radiation therapy.
  • Patients combined with coagulopathy.

Treatment and study plan

Primary outcomes

  1. Genetic information of lung cancer patients

    Time frame: One week after the study subjects sign the permit of informed consents

    Collect study subjects' blood sample and analysis with Genome-wide SNP genotyping

Study contacts

Contact information is provided by the study sponsor or research team.

Jin-Shing Chen, PhD

CONTACT

[email protected]

+8869721451

Tung-Ming Tsai, MD

CONTACT

[email protected]

+886972792011

Sponsors and collaborators

Lead sponsor

National Taiwan University Hospital

Other

Registry information

Important dates

Study start
2017
Primary completion
2020
Study completion
2037
First posted
Jul 31, 2017
Registry last updated
Aug 1, 2017

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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