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NCT Number: NCT06929780

A Prediction Model of Prolonged Mechanical Ventilation Following Acute Type A Aortic Dissection Surgery

The goal of this observational study is to develop and validate a predictive model for prolonged mechanical ventilation (PMV) following acute type A aortic dissection (ATAAD) surgery.

The main questions it aims to answer are:

1. To validate the predictive performance of the model for PMV after ATAAD surgery 2. To assess the proportion of PMV among patients undergoing ATAAD surgery 3. To evaluate the ICU length of stay and operative mortality in patients with PMV following ATAAD surgery

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Key information

Conditions

Acute Type A Aortic Dissection

Age range

18 year–18 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Age ≥18 years;
  • Diagnosis of acute type A aortic dissection (ATAAD) confirmed by computed tomography angiography and echocardiography;
  • Patients who underwent aortic surgery requiring cardiopulmonary bypass (CPB), were admitted to the surgical intensive care unit (SICU), and received mechanical ventilation.

Exclusion criteria

  • Reintubation;
  • Intraoperative death or failure to survive beyond 72 hours postoperatively;
  • Pregnancy;
  • Severe comorbidities (e.g., lung cancer);
  • Missing critical outcome data (e.g., short-term mortality, mechanical ventilation duration, reintubation).

Treatment and study plan

Primary outcomes

  1. The predictive performance of the model for prolonged mechanical ventilation (PMV) following acute type A aortic dissection (ATAAD) surgery

    Time frame: 72 hours after ATAAD surgery

    The predictive performance of PMV following ATAAD surgery includes its discriminative ability and calibration ablility.

  2. The proportion of patients with PMV

    Time frame: 72 hours after ATAAD surgery

    The proportion of patients with PMV refers to the proportion of patients with PMV among the total included ATAAD postoperative patients. PMV is defined as postoperative mechanical ventilation lasting more than 72 hours

Secondary outcomes

  1. ICU length of stay (ICU-LOS)

    Time frame: From surgery to discharge or death, whichever came first, assessed up to 6 months

    ICU length of stay was defined as the length of time spent in ICU from surgery to discharge or death.

  2. surgery-related mortality

    Time frame: 30 days after ATAAD surgery

    surgery-related mortality encompassed any death occurring during the index hospitalization (even beyond 30 days) or after discharge but before postoperative day 30.

Study contacts

Contact information is provided by the study sponsor or research team.

Zhang Qin, Dr

CONTACT

[email protected]

+86 18990236167

Zhou Xiaoming, Dr

CONTACT

[email protected]

010-68314466

Sponsors and collaborators

Lead sponsor

China-Japan Friendship Hospital

Other

Registry information

Official study title

Prolonged Mechanical Ventilation Following Acute Type A Aortic Dissection Surgery: Risk Factor Analysis, Impact on Clinical Outcomes and Development of Prediction Model

Important dates

Study start
2025
Primary completion
2025
Study completion
2025
First posted
Apr 16, 2025
Registry last updated
Apr 16, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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