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Recruiting

NCT Number: NCT06741137

A Pilot Study of the Effect of the Combination of Inhaled Nitric Oxide and Prone Position Under EIT Monitoring on Efficacy in Patients with ARDS

Investigating the Impact of Combined Inhaled Nitric Oxide and Prone Positioning on the Efficacy in ARDS Patients

Recruiting

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Key information

Conditions

Age range

18 year–80 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Northern Jiangsu People's Hospital

Yangzhou, Jiangsu, 211400, China

Location status: Recruiting

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Age 18-80 years;
  • Patients with moderate to severe ARDS on mechanical ventilation

Exclusion criteria

  • Patients with severe asthma or acute exacerbation of chronic obstructive pulmonary disease (COPD), lung tumors, post-lung resection, and post-lung transplantation.
  • Patients with hemodynamic instability requiring vasopressor support: dopamine or dobutamine >15 µg/kg/min, norepinephrine >0.3 µg/kg/min.
  • Cardiogenic pulmonary edema.
  • Patients with severe facial deformities, facial trauma, or severe thoracoabdominal trauma that precludes prone positioning ventilation.
  • Mid to late pregnancy.
  • Patients with a history of malignancy or other irreversible diseases/conditions, including those in the terminal stage.
  • Patients expected to be discharged soon or requiring invasive mechanical ventilation for less than 24 hours.
  • Patients currently participating in other studies.

Treatment and study plan

inhaled nitric oxide combined with prone position ventilation

Procedure

inhaled nitric oxide combined with prone position ventilation

Primary outcomes

  1. Intratidal gas distribution

    Time frame: 12 hours

Study contacts

Contact information is provided by the study sponsor or research team.

Chuanqing Zhang Study Director

CONTACT

[email protected]

1504572590

Sponsors and collaborators

Lead sponsor

Northern Jiangsu People's Hospital

Other

Registry information

Important dates

Study start
2024
Primary completion
2025
Study completion
2025
First posted
Dec 18, 2024
Registry last updated
Jan 10, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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