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NCT Number: NCT07486661

A Pilot Project for PLWH Aged 65-75: Preventing the Development of Frailty

In ageing populations, the main risk is the development of a syndrome of frailty, characterized by the addition of polymorbidity, polymedication, psychosocial difficulties, cognitive disorders, ... This functional decline is linked to a reduction in the person's functional reserves, and will lead to an increase in health problems, hospitalizations and, ultimately, mortality. People living with HIV (PLWH) over 50 develop the same kind of comorbidities as HIV-uninfected people over 75 years-old.

In Belgium, the care of PLWH< 75 years with frailty syndrome is not reimbursed by healthcare insurance, and geriatric assessment and management is therefore not possible in this age group, despite the very real need.

Goals of this project are:

1. Determine the proportion and characterize the population of PLWH aged 65 and over who screen positive using the Fried scale 2. Validate the application of the Fried scale in a population of PLWH 3. Offer a care pathway model to prevent the onset of frailty in people screened as at-risk and who do not benefit from routine screening or care pathway reimbursement.

Projets proposal:

* Systematic screening of all PLWH aged 65-74 at the MIA Center, by the nurse prior to physician consultation, using the Fried scale. * Send all PLWH aged 65-74 who screen positive to Geriatric One Day for an ergo-geriatric consultation to confirm the risk of frailty and set up a preventive care pathway * After treatment, perform a patient satisfaction questionnaire + a new Fried scale at one year

Recruiting

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Key information

Age range

65 year–74 year

Sex eligibility

All sexes

Study type

Observational

Primary location

CHU Saint-Pierre, centre MIA

Brussels, 1000, Belgium

Location status: Recruiting

Location contact

Agnes Libois, MD

CONTACT

[email protected]

+3225354130

Agnes Libois, MD

PRINCIPAL_INVESTIGATOR

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • living with HIV
  • between 65-74 years

Exclusion criteria

  • none

Treatment and study plan

Primary outcomes

  1. number of PLWH between 65 and 74 years with frailty

    Time frame: Baseline

    Using Fried scale and complete geriatic assesment The Fried scale is a widely recognized assessment tool designed to evaluate frailty in older adults, particularly those aged 65 and above. It helps identify individuals at increased risk of adverse health outcomes, such as falls, hospitalization, disability, and mortality. The assessment is based on five key criteria: unintentional weight loss, exhaustion, low physical activity, slowness, and weakness, with each positive criterion scoring one point.

    Scores of 0 indicate a robust individual, 1-2 suggest a state of pre-frailty, and ≥3 confirm frailty.

Secondary outcomes

  1. Number of PLWH with a Fried test detecting frailty

    Time frame: Baseline

    Fried scale

  2. Number of PLWH with Fried scale detecting pre-frailty condition

    Time frame: Baseline

    Fried scale

  3. Results of Fried scale at one year

    Time frame: one year after the first Fried scale performed at baseline

    Fried scale performed one year after the first Fried scale in those with a abnormal Fried scale at baseline ( >/=2)

Other outcomes

  1. Validate the application of the Fried scale in a population of PLWH

    Time frame: This analyse will be done at the end of the study when all patients will have complete the evaluation at one year.

    compared the number of the PLWH with an Fried scale of a score >/= 2 and the number of PLWH with frailty assessed by a complete geriatrician estimation

Study contacts

Contact information is provided by the study sponsor or research team.

Agnes LIBOIS, MD

CONTACT

[email protected]

+3225354130

Charlotte Martin, MD, PHD

CONTACT

[email protected]

+3225354130

Sponsors and collaborators

Lead sponsor

Centre Hospitalier Universitaire Saint Pierre

Other

Registry information

Acronym: Frailty

Important dates

Study start
2025
Primary completion
2028
Study completion
2028
First posted
Mar 20, 2026
Registry last updated
Mar 20, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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