A Phase I Study of TS-172 in Healthy Adult Subjects (Single and Multiple Doses)

Inclusion criteria

• Japanese healthy males aged 20 years or older but less than 40 years at the time of informed consent
• Those with a BMI of 18.5 or more and less than 25.0 at screening test
• Those who are able to receive the explanation before participating in the study, understand the content of the study, and provide written informed consent by the subjects themselves.

Exclusion criteria

• Subjects who have any disease and are not considered healthy subjects based on the medical judgment of the principal investigator or sub-investigator.
• Those who correspond to any of the following about bowel movements;

• Repeated diarrhea (Bristol Stool Form Score [BSFS] score of 6 or higher) on a daily basis
• Repeated constipation (no defecation for 2 days or more in a week) on a daily basis
• Those who correspond to any of the following about bowel movements in the 7 days before administration;

• Diarrhea on 2 or more days in 7 days
• 2 or more days without a bowel movement in 7 days
• Those who have a history of gastrointestinal ulceration
• Those who correspond to any of the following about infection;

• Positive for SARS-CoV-2 in the nucleic acid amplification test performed at the time of admission
• Suspected of having COVID-19