A Pharmacokinetic Study of Cefepime After Administration Into Dialysate in Patients With Continuous Ambulatory Peritoneal Dialysis (CAPD) Peritonitis

Cefepime is a broad-spectrum antibiotic used in treating CAPD peritonitis. However, medical knowledge has been lacking with regard to its pharmacokinetic profile after it has been administered intraperitoneally. The current study aims at determining the drug level at different time after the drug has been added into the peritoneal fluid in patients with CAPD peritonitis. The results of this study will finally leads to rational prescription of this drug at correct dosages.

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Key information

Conditions

Peritonitis Digestive System Diseases Infections Intraabdominal Infections Peritoneal Diseases

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Caritas Medical Centre, Hong Kong, China

Who can participate

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Age >= 18 years & has been put on CAPD for >= 4 weeks before entering into the study

Exclusion criteria

Known hypersensitivity to cefepime or other cephalosporin; CAPD peritonitis <= 28 days before being enrolled into the study
Antibiotic treatment within 1 week prior to entry into the study
Severe exit site or tunnel infection on the day of presentation
Any conditions that prompt early removal of Tenckhoff catheter irrespective of clinical response to antibiotic treatment
Abdominal malignancy; Any surgical causes of peritonitis
Suspected or known fungal or tuberculous peritonitis
History of dementia or known mental incompetency

Treatment and study plan

Intraperitoneal Cefepime

Drug

Sponsors and collaborators

Lead sponsor

Hospital Authority, Hong Kong

Other Gov

Registry information

Official study title

Research Study on the Pharmacokinetic Profile of Intraperitoneal Cefepime in Patients With Continuous Ambulatory Peritoneal Dialysis (CAPD) Peritonitis

Important dates

Study start: 2005
Study completion: 2007
First posted: Jul 9, 2007
Registry last updated: Jun 16, 2011

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed