A Pharmacokinetic Evaluation of Metformin in Relation to the Polymorphism A270S in Healthy Caucasian Volunteers

The aim of the study is to evaluate the pharmacokinetics of metformin in healthy Caucasians volunteers with and without the polymorphism A270S in OCT2,thus the study hypothesis is that renal clearance of metformin is affected in Caucasian with the known single nucleotide polymorphisms A270S in OCT2.

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Key information

Conditions

Metformin Diabetes Mellitus Diabetes Mellitus, Type 2 Endocrine System Diseases Glucose Metabolism Disorders Metabolic Diseases Nutritional and Metabolic Diseases Organic Cation Transporter 2 Polymorphism,Single Nucleotide

Age range

18 year–65 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Phase 4

Primary location

Institute of Public Health, Clinical Pharmacology, University of Southern Denmark

Odense, 5000, Denmark

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Healthy volunteers
Written consent
rs316019 genotyped
Age 18-65 years old

Exclusion criteria

Daily medication
Alcohol abuse
Pregnancy
Breastfeeding

Treatment and study plan

metformin

Drug

A single dose study with one tablet of metformin 500 mg, time frame 24 hours

Other names: Orabet

Primary outcomes

Renal clearance of metformin

Time frame: 24 Hours

Sponsors and collaborators

Lead sponsor

University of Southern Denmark

Other

Registry information

Official study title

A Pharmacokinetic Evaluation of Metformin in Relation to the Polymorphism A270S in Healthy Caucasian Volunteers.

Important dates

Study start: 2010
Primary completion: 2010
Study completion: 2010
First posted: Nov 9, 2010
Registry last updated: Dec 29, 2010

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed