(A Novel Pharmacologic Regime for Elective Percutaneous Coronary Intervention)

Aim:

Primary objective:To evaluate the efficiency and safety of low dose intracoronary unfractioned heparin (UFH) on elective percutaneous coronary intervention (PCI).

Secondary objective:

• To evaluate the effect of low dose intracoronary UFH on myocardial ischemia after PCI.
• To evaluate the effect of low dose intracoronary UFH on bleeding complications after PCI.
• To evaluate the cost-effectivity of low dose intracoronary UFH on elective PCI

Study central:

• Bursa Postgraduate Hospital, Cardiology Clinic

Study population:

• we planned to enrol 200 patients.
• Patients will randomise in two groups (control group:100 patients, study group:100 patients)

Study works:-Write case report form for all patients

• Control for inclusion criteria
• Demographic data (age, gender)
• Height, weight, BMI and glomerular filtration rate (GFR)
• Risk factors
• laboratory data (biochemical and hematologic)
• Medication history
• Echocardiographic data
• Angiographic data
• Procedure time
• PCI data(vessel diameter, stent diameter, lesion and stent length, performed percutaneous transluminal coronary angioplasty (PTCA) or not, etc)
• Before and after procedure (activated clotting time) ACT value
• Before and after procedure troponin I (TnI) and Creatine kinase MB (CKMB) levels
• Note complication (MACE, bleeding, hematoma etc)
• Note femoral compression time.

4 weeks later note the first control data.

Six months later note the second control data.

Inclusion criteria

• The patients; who have planned elective PCI and have had written informed consent for participation to study.
• The native coronary artery;

• lesion with narrowing >=70%,
• lesion without thrombus
• no left main coronary artery (LMCA) lesion
• no chronic total occlusion lesion

Exclusion criteria

• Patients have allergy for acetylsalicylic acid (ASA), Clopidogrel and heparin
• Patients who performed primary PCI
• Patients with acute coronary syndrome
• Patients with have a history of myocardial infarction (MI) for two weeks
• Patients who were use UFH or low molecular weight heparin (LMWH) for 24 hours
• Patients on warfarin therapy
• Patients who have bleeding diathesis, or have high risk for bleeding.