A Novel Ferumoxytol-enhanced Cardiac Magnetic Resonance for the Detection of Calcified Coronary Arteries

Inclusion criteria

• Age ≥18 years, <75 years;
• Imaging specialists evaluate CCTA images taken within 30 days and report that calcification occupied one or more of the patient's vascular lumen at an angle of >50% (using the coronary artery segmentation method recommended by the American Heart Association, including nine segments of the major branches of the coronary artery);
• Patient who will undergo coronary angiography;
• Patient with normal renal function or chronic renal insufficiency (CKD) stage 1-3;
• Patient who signs the informed consent.

Exclusion criteria

• People who are allergic to iodine contrast media or have a history of allergy to iron or dextran or are allergic themselves;
• Because of psychological (such as suffering from claustrophobic syndrome) or physical reasons (such as the presence of metal objects in the body) can not receive MRI examination;
• suffering from terminal diseases (such as malignant tumors) or life expectancy < 1 year;
• Pregnant or lactating women;
• People with limited hearing;
• Patients with grade III-IV heart function;
• Patients with a history of coronary artery stent implantation or coronary artery bypass;
• Other iron agents are being used orally or intravenously;
• Patients with hemosiderosis or hemochromatosis;
• Patients with acute coronary syndrome;
• Patients with hyperthyroidism;
• Any other candidates deemed unsuitable by the researchers.