A Novel Appendicitis TriMOdal Prediction Score (ATMOS) for Acute Appendicitis in Pregnancy: a Retrospective Observational Study

Acute appendicitis (AA) is a disease of younger age, but it occurs in 1 out of 500-2000 pregnancies. The current treatment of choice for AA in pregnancy is surgical. Even with standard clinical examination, serum inflammatory markers, and transabdominal ultrasound, the decision on surgical treatment of acute appendicitis (AA) and the rate of negative appendectomy in pregnancy are still unsatisfactory. There are several scoring systems (Alvarado, Tzanakis) that help making decision on operating more easier, however their specificity is either high with low sensitivity, or the other way around. In addition, all scores are based on adult non-pregnant population. We are making an observational study to develop a scoring system that would include ultrasonic imaging with clinical-biochemical parameters while not compromising sensitivity and specificity.

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Key information

Conditions

Appendicitis in Pregnancy Appendicitis Cecal Diseases Digestive System Diseases Gastroenteritis Gastrointestinal Diseases Infections Intestinal Diseases Intraabdominal Infections

Age range

18 year and older

Sex eligibility

Female

Study type

Observational

Primary location

University Hospital Center Zagreb

Zagreb, 10000, Croatia

About this study

The study includes extraction of medical data for pregnant women, age 18 years or older, admitted to the University Hospital Centre Zagreb, Zagreb, Croatia, with the suspicion of AA, from January 2010 to December 2020. The aim of this study is to develop a scoring system that would include ultrasonic imaging with clinical-biochemical parameters while not compromising sensitivity and specificity.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

pregnant women, age 18 years or older, admitted to the University Hospital Centre Zagreb, Zagreb, Croatia, with the suspicion of acute appendicitis, from January 2010 to December 2020.

Exclusion criteria

non-pregnant patients
pregnant patients younger than 18 years
diagnosis made with CT or MRI
pregnant patients with the acute abdomen (intraoperative diffuse peritonitis) from acute appendicitis

Treatment and study plan

Primary outcomes

Predictive factors of acute appendicitis in pregnancy

Time frame: January 2010 to December 2020

Detection of predictive factors of acute appendicitis in pregnancy

Sponsors and collaborators

Lead sponsor

Clinical Hospital Centre Zagreb

Other

Collaborators

Goran Augustin
Mislav Herman
Ognjen Barcot
Salvatore Giovanni Vitale

Registry information

Acronym: ATMOS

Important dates

Study start: 2021
Primary completion: 2021
Study completion: 2021
First posted: Jan 21, 2022
Registry last updated: Aug 11, 2022

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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Completed