Skip to main content
OpenTrials
Completed

NCT Number: NCT03813914

A New Supplement for the "Metabolic Syndrome"

This study evaluates the effect of a combination of glycirrhizic acid, Cinnamomun Zeylanicum and corosolic acid for the treatment of metabolic syndrome. Participants receive the supplement or a placebo.

Completed

Looking for future studies?

Notify Me

Key information

Conditions

Metabolic Syndrome Glucose Metabolism Disorders Hyperinsulinism Insulin Resistance Metabolic Diseases Nutritional and Metabolic Diseases

Age range

45 year–65 year

Sex eligibility

Female

Study type

Interventional

Phase

Not applicable

About this study

The supplement is composed by of a combination of glycirrhizic acid, Cinnamomun Zeylanicum and corosolic acid. They act in different way reducing insulin resistance, which is the main cause of metabolic syndrome. It was a randomized, controlled study involving 60 women with the metabolic syndrome following the criteria proposed by ATP III in 2015. Main outcomes were the improvement of the parameters that characterizes the metabolic syndrome, such as glucose and insulin levels, triglycerides, HDL-cholesterol and blood pressure.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Postmenopausal women affected by Metabolic Syndrome, diagnosed by ATP 2015 criteria.

-

Exclusion criteria

treatment with steroids or with hypoglycemic or anti-cholesterol drugs

-

Treatment and study plan

Sineos

Dietary Supplement

glycyrrhizic acid 38 mg + Cinnamomum Zeylanicum 150 mg + corosolic acid 480 mcg 2 pills per day

Primary outcomes

  1. Changes in glycemia

    Time frame: 3 months

    Reduction of glycemia (mg/dl)

  2. Changes in HDL-cholesterol

    Time frame: 3 months

    Increase of HDL-C (mg/dl)

Secondary outcomes

  1. changes in HOMA-IR

    Time frame: 3 months

    measured as the ratio between glycaemia (mg/dl) and insulin (UI)

  2. changes in total-cholesterol

    Time frame: 3 months

    reduction of cholesterol (mg/dl)

  3. changes in triglycerides

    Time frame: 3 months

    reduction in triglycerides (mg/dl)

Sponsors and collaborators

Lead sponsor

University of Messina

Other

Registry information

Official study title

Corosolic Acid and Cinnamon for the Treatment of the "Metabolic Syndrome" in Menopausal Transition Women

Important dates

Study start
2017
Primary completion
2018
Study completion
2018
First posted
Jan 23, 2019
Registry last updated
Jan 23, 2019

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Related clinical trials

Published trials that share one or more normalized conditions with this study.