A New Marker for Early Diagnosis of Pneumoperitoneum-Related Acute Kidney Injury: Insulin-Like Growth Factor-1 (IGF-1)

In our study, to show the effect of pneumoperitoneum on acute kidney injury in patients scheduled for laparoscopic surgery, NGAL and IGF-1 values will be measured before, after and 24 hours after pneumoperitoneum, and these values will be compared. In our study, we aimed to investigate the effect of pneumoperitoneum applied on acute kidney injury in patients who underwent laparoscopic surgery. Creatinine and NGAL have been used successfully in the follow-up of acute kidney injury. Our study investigates whether IGF-1 will be an effective indicator in acute kidney injury by comparing IGF-1 and NGAL values before pneumoperitoneum, after pneumoperitoneum and at the postoperative 24th hour.

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Key information

Conditions

Acute Kidney Injury (Nontraumatic) Acute Kidney Injury Digestive System Diseases Female Urogenital Diseases Female Urogenital Diseases and Pregnancy Complications Kidney Diseases Male Urogenital Diseases Peritoneal Diseases Pneumoperitoneum Renal Insufficiency Urogenital Diseases Urologic Diseases

Age range

18 year–70 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Çağla Yazar, MD

Ankara, 06560, Turkey (Türkiye)

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Patients aged 18-70 years of both sexes
ASA I-III Patients

Exclusion criteria

Obesity,
Chronic Kidney Disease,
Chronic Renal Failure,
Acute Renal Failure,
Peripheral and ischemic vascular disease,
Chronic Heart Failure,
History of anaphylaxis,
A-V block,
Creatinine level >1.4,
Neuromuscular disease,
Malignant hypertension,
Pyelonephritis,
Urinary tract infectio,
Severe inflammation/possible sepsis,
Active malignancy,
Patients with surgery reversion to laparotomy,
Hemodynamic instability, need for vasopressors,
Severe bleeding requiring blood transfusion,

Treatment and study plan

IGF-1

Diagnostic Test

We need to diagnose acute kidney injury in the early postoperative period. The markers examined so far do not provide enough information to diagnose acute kidney injury early. For this reason, many different biomarkers are used in the early diagnosis of acute kidney injury in many parts of the world. Thanks to our research, we can recognise the development of acute kidney injury at an early stage and determine whether a previously unused biomarker (IGF-1) is effective in the early diagnosis of acute kidney injury.

Primary outcomes

Diagnosis of acute kidney injury in the early postoperative period with IGF-1 (insulin like growth factor-1)

Time frame: before pneumoperitoneum, after pneumoperitoneum, and at the postoperative 24th hour.

The researchers investigate whether IGF-1 will be an effective indicator in acute kidney injury by comparing IGF-1 and NGAL (Neutrophil gelatinase-associated lipocalin) values before pneumoperitoneum, after pneumoperitoneum and at the postoperative 24th hour.

Sponsors and collaborators

Lead sponsor

Baskent University

Other

Registry information

Important dates

Study start: 2023
Primary completion: 2023
Study completion: 2023
First posted: Nov 10, 2022
Registry last updated: Jan 5, 2024

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed