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Enrolling by Invitation

NCT Number: NCT07018544

A Multicentre, Prospective, Single-arm, Non-interventional Regulatory Post-marketing Surveillance (rPMS) Study to Investigate the Safety and Effectiveness of Wegovy® (Semaglutide) in Patients With Obesity and Patients With Overweight in Routine Clinical Practice in Korea

This study is conducted to investigate the safety and effectiveness of semaglutide in participants with obesity and overweight in routine clinical practice. Participants will get semaglutide as prescribed by a doctor. This study will last for about 4 years and participants will participate in the study for approximately 26 weeks.

Enrolling by Invitation

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Key information

Age range

19 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

MyongJi Hospital, Goyang-si, Gyeonggi-do, South Korea

Loading trial locations.

Who can participate

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Signed consent obtained before any study-related activities (study-related activities are any procedure related to recording of data according to the protocol).
  • The decision to initiate treatment with commercially available semaglutide has been made by the participants and the treating physician before and independently from the decision to include the participant in this study.
  • Male or female adults, age above or equal to 19 years who is scheduled to start treatment with semaglutide based on the clinical judgment of their treating physician as specified in the Korean-prescribing Information (approved label in Korea) at the time of signing informed consent.

Exclusion criteria

  • Participants who are or have previously been on semaglutide therapy before enrollment.
  • Known or suspected hypersensitivity to the active substance or any of the excipients of semaglutide.
  • Previous participation in this study. Participation is defined as having given informed consent in this study.
  • Female participant who is pregnant, breast-feeding, or intends to become pregnant and is of childbearing potential not using adequate contraceptive methods (adequate contraceptive measures as required by local regulation or practice).
  • Mental incapacity, unwillingness or language barriers precluding adequate understanding or cooperation.

Treatment and study plan

semaglutide

Other

Participants will be treated with commercially available semaglutide according to routine clinical practice at the discretion of the treating physician.

Other names: Wegovy

Primary outcomes

  1. Number (incidence) of AEs

    Time frame: From Visit 1 (baseline, 0 week) to Visit 4 (22 weeks < ~ ≤ 30 weeks)

    Count of events

Secondary outcomes

  1. Number (incidence) of ADRs

    Time frame: From Visit 1 (baseline, 0 week) to Visit 4 (22 weeks < ~ ≤ 30 weeks)

    Count of events

  2. Number (incidence) of SAEs

    Time frame: From Visit 1 (baseline, 0 week) to Visit 4 (22 weeks < ~ ≤ 30 weeks)

    Count of events

  3. Number (incidence) of SADRs

    Time frame: From Visit 1 (baseline, 0 week) to Visit 4 (22 weeks < ~ ≤ 30 weeks)

    Count of events

  4. Number (incidence) of unexpected AEs

    Time frame: From Visit 1 (baseline, 0 week) to Visit 4 (22 weeks < ~ ≤ 30 weeks)

    Count of events

  5. Number (incidence) of unexpected ADRs

    Time frame: From Visit 1 (baseline, 0 week) to Visit 4 (22 weeks < ~ ≤ 30 weeks)

    Count of events

  6. Number (incidence) of unexpected SAEs

    Time frame: From Visit 1 (baseline, 0 week) to Visit 4 (22 weeks < ~ ≤ 30 weeks)

    Count of events

  7. Number (incidence) of unexpected SADRs

    Time frame: From Visit 1 (baseline, 0 week) to Visit 4 (22 weeks < ~ ≤ 30 weeks)

    Count of events

  8. Total dose of semaglutide

    Time frame: From Visit 1 (baseline, 0 week) to Visit 4 (22 weeks < ~ ≤ 30 weeks)

    Milligram/milliliter (mg/mL)

  9. Body weight loss

    Time frame: From Visit 1 (baseline, 0 week) to Visit 4 (22 weeks < ~ ≤ 30 weeks)

    Percent (%)

  10. Body weight loss

    Time frame: From Visit 1 (baseline, 0 week) to Visit 4 (22 weeks < ~ ≤ 30 weeks)

    Kilogram (kg)

  11. The proportion of participants losing greater than or equal to 5% body weight

    Time frame: From Visit 1 (baseline, 0 week) to Visit 4 (22 weeks < ~ ≤ 30 weeks)

    Percent (%)

  12. The proportion of participants losing greater than or equal to 10% body weight

    Time frame: From Visit 1 (baseline, 0 week) to Visit 4 (22 weeks < ~ ≤ 30 weeks)

    Percent (%)

  13. The proportion of participants losing greater than or equal to 15% body weight

    Time frame: From Visit 1 (baseline, 0 week) to Visit 4 (22 weeks < ~ ≤ 30 weeks)

    Percent (%)

Sponsors and collaborators

Lead sponsor

Novo Nordisk A/S

Industry

Registry information

Official study title

A Multicentre, Prospective, Single-arm, Non-interventional Regulatory Post-marketing Surveillance (rPMS) Study to Investigate the Safety and Effectiveness of Wegovy® (Semaglutide) in Patients With Obesity and Patients With Overweight in Routine Clinical Practice in Korea.

Important dates

Study start
2024
Primary completion
2027
Study completion
2027
First posted
Jun 12, 2025
Registry last updated
Jun 12, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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