Completed

NCT Number: NCT00174512

A Methodological Open Label Cross-Over Controlled Study To Assess The Effect Of Drugs On Ventricular Repolarization and QT Interval At Fixed Heart Rate Under Autonomic Blockade

To assess the effects of GTN on QT and QTc in subjects with And without atrial pacing. This will be done with and without autonomic blockade at two different pacing rates. Moxifloxacin effect on QT and QTc will also be assessed in atrially paced patients at two different pacing rates with and without autonomic blockade

Completed

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Key information

Conditions

Patients With Pace Makers But no Evidence of Ischemic Heart Disease

Age range

18 year–75 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Phase 1

Primary location

Pfizer Investigational Site, Bruxelles (Brussels), Belgium

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Patients with pace-makers but otherwise normal ventricular function

Exclusion criteria

Nitrates, beta blockers

Treatment and study plan

GTN

Drug

moxifloxacin

Drug

Primary outcomes

QT and QTc changes at two different pacing rates in atrially paced patients

Secondary outcomes

Change in QT and QTcF before and after Moxifloxacin with and without autonomic blockade at each pacing rate Change in QT and QTcF before and after autonomic blockade at each pacing rate

Sponsors and collaborators

Lead sponsor

Pfizer

Industry

Registry information

Official study title

A Methodological Open-Label Cross-Over Controlled Study To Assess The Effect Of Drugs On Ventricular Repolarisation and QT Interval At Fixed Heart Rate Under Autonomic Blockade

Important dates

Study start: 2005
Study completion: 2006
First posted: Sep 15, 2005
Registry last updated: Nov 8, 2006

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.