A Master Protocol for Orforglipron (LY3502970) in Participants With Hypertension and Obesity or Overweight: (ATTAIN-Hypertension Screening)

Inclusion criteria

• Has systolic blood pressure (SBP) ≥ 140 mmHg and/or diastolic blood pressure (DBP) ≥ 90 mmHg (if DBP criteria alone is met, SBP must be ≥130 mmHg) at screening (Visit 1).
• Has SBP ≥ 140 mmHg and/or DBP ≥ 90 mmHg (if DBP criteria alone is met, SBP must be ≥130 mmHg) at week 0 (Visit 3).
• Untreated for hypertension, or on stable antihypertensive medications ≥ 30 days prior to Visit 1.
• Have a body mass index (BMI) ≥ 25 kg/m².

Exclusion criteria

• Has SBP ≥170 mmHg and/or DBP ≥110 mmHg at Visit 1 or at Visit 3.
• Has known secondary causes of hypertension
• Have heart failure with reduced ejection fraction (HFrEF) diagnosis
• Have had any of the following conditions within 90 days prior to screening.

• hospitalization for hypertension or for congestive heart failure
• acute coronary syndrome or acute myocardial infarction, or
• cerebrovascular accident (stroke).
• Have type 1 diabetes (T1D)
• Have acute or chronic hepatitis, including a history of autoimmune hepatitis