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Completed

NCT Number: NCT01243684

A Magnetic Resonance Imaging Study of Patients With Cervical Spondylosis

This study aims at evaluating spinal cord structure using diffusion tensor imaging in patients with cervical spondylosis.

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Key information

Conditions

Cervical Spondylosis Bone Diseases Central Nervous System Diseases Musculoskeletal Diseases Nervous System Diseases Spinal Cord Diseases Spinal Diseases Spondylosis

Age range

18 year–70 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Cochin Hospital, Radiology B

Paris, Île-de-France Region, 75014, France

About this study

Diffusion tensor imaging (DTI) of the cervical spinal cord will be performed in patients with cervical spondylosis with varying degrees of symptoms and in healthy control subjects. Fibre tracking of main spinal tracts will be performed. Regions of interest will also be identified. Diffusion parameters will be extracted. This will allow quantification of degree of damage in of the spinal cord. The findings will be related to motor function measures and comprehensive clinical tests of sensory and motor function.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • 18-70 years old
  • Sufficiently cooperative
  • Cognitively understands study and implications
  • Signed informed consent
  • Symptomatic cervical spondylosis

Exclusion criteria

  • MRI contraindications (e.g., pacemaker, metal implants, claustrophobia)
  • Previous pathology that would impact behavioural measures
  • Anxiety and poor cooperation
  • Previous neurological condition
  • Pregnancy

Treatment and study plan

DTI - Diffusor Tensor Imaging

Device

Radiology intervention

Primary outcomes

  1. DTI parameters in cervical spinal cord

    Time frame: 3 weeks

Secondary outcomes

  1. Clinical data, i.e., Muscle testing, sensory testing, reflexes, spasticity, and Motor function (dexterity test), grip strength

    Time frame: 3 weeks

    Clinical data, i.e., Muscle testing, sensory testing, reflexes, spasticity

    Motor function (dexterity test), grip strength

Sponsors and collaborators

Lead sponsor

Assistance Publique - Hôpitaux de Paris

Other

Collaborators

  • URC-CIC Paris Descartes Necker Cochin

Registry information

Official study title

Structural Spinal Cord Integrity in Patients With Cervical Spondylosis in Relation to Clinical Status

Acronym: Tractocervical

Important dates

Study start
2010
Primary completion
2012
Study completion
2014
First posted
Nov 18, 2010
Registry last updated
Feb 13, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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