Skip to main content
OpenTrials
Completed

NCT Number: NCT01152515

A Low Dose Remifentanil Infusion During Tracheal Extubation in Surgical Intensive Care Unit Patients

Tracheal extubation can be associated with hyperdynamic circulatory response. The investigators examined the effect of maintaining a remifentanil infusion on the cardiovascular response during extubation in propofol-remifentanil sedated patients after surgery.

Completed

Looking for future studies?

Notify Me

Key information

Conditions

Tracheal Extubation

Age range

20 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Phase 4

Primary location

Department of Anesthesiology and Pain Medicine and Anesthesia and Pain Research Institute, Yonsei University College of Medicine

Seoul, 120-752, South Korea

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Age ≥ 20
  • Short term ventilator care after surgery in intensive care unit

Exclusion criteria

  • pneumonia
  • chronic obstructive lung disease
  • asthma
  • end stage renal disease
  • risk factors for aspiration

Treatment and study plan

Remifentanil

Drug

Control group : stopping of propofol and remifentanil infusion Remifentanil group : stopping of propofol and maintenance of remifentanil infusion

Primary outcomes

  1. Mean Arterial Pressure Changes During Extubation

    Time frame: 10 min

  2. HR Changes During Extubation

    Time frame: 10 min

  3. The Grade of Coughing During Extubation

    Time frame: 2 min

    Grade of cough was assessed on a four-point scale (0=no coughing, 1=single cough, 2=more than one episode of nonsustained coughing, 3=sustained and repetitive coughing with head lift).

Secondary outcomes

  1. Time of Awake

    Time frame: 1 hour

    Time of BIS > 80 : time between 'stopping of propofol'

  2. Time of Extubation

    Time frame: 1 hr

    Time of extubation : time between 'stopping of propofol' and 'extubation'

Sponsors and collaborators

Lead sponsor

Severance Hospital

Other

Registry information

Important dates

Study start
2010
Primary completion
2011
Study completion
2011
First posted
Jun 29, 2010
Registry last updated
Mar 27, 2020

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Related clinical trials

Published trials that share one or more normalized conditions with this study.