A Drug Drug Interaction (DDI) Study of Pirtobrutinib (LY3527727) and Rosuvastatin in Healthy Participants

Inclusion criteria

• Participants who are overtly healthy as determined by medical evaluation including medical history, physical examination, and vital signs.
• Body mass index (BMI) within the range of 18.0 to 32.0 kilograms per meter squared (kg/m²) and a body weight of at least 50 kg.
• Males, or female participants who are not of childbearing potential.

Exclusion criteria

• Have known allergies to pirtobrutinib or rosuvastatin, related compounds, or any components of the formulation.
• Have an abnormal blood pressure and/or pulse rate, deemed to be clinically significant by the investigator.
• Have a significant history of or current cardiovascular, respiratory, hepatic, renal, gastrointestinal, endocrine, hematological, neurological, or psychiatric disorder or surgery (including cholecystectomy) capable of significantly altering the absorption, metabolism, or elimination of drugs; of constituting a risk when taking the investigational product; or of interfering with the interpretation of data.
• Have used or intend to use prescription or nonprescription medication (including dietary supplements, vitamins, and/or herbal medications), or modulators of CYP3A4 or BCRP within 7 days prior to dosing, unless, in the opinion of the investigator and sponsor, the medication will not interfere with the study.
• Have c.34AA, c.421AA, or c.34GA/421CA genotypes of ABCG2 as determined through genotyping.
• Have c.521TC and c/521CC genotypes of SLCO1B1 as determined by genotyping.