Skip to main content
OpenTrials
Completed

NCT Number: NCT01916642

A Dose-response Study of Lidocaine and Etomidate

IV lidocaine administration can reduce the minimal amount of Etomidate and time for induction of anesthesia.

Completed

Looking for future studies?

Notify Me

Key information

Conditions

Etomidate Overdose of Undetermined Intent

Age range

18 year–70 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Phase 1

About this study

The study was carried out in West China Hospital of Sichuan University, Chengdu, China. All the patients were informed in detail about the procedure and the medications they are going to get. Patients are well informed about the beneficial and possible hazards of the medicines and procedure. Patients are also informed that they can withdraw from the study at any time if they find it uncomfortable or harmful for them. Patients' written informed consent was obtained and registered for the permission from the Hospital's Ethics Board.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Patients scheduled for Elective Surgery,
  • age limit within 18-70 years,
  • American Society of Anaesthesiologists physical status classification I-II

Exclusion criteria

  • Adrenal Cortex disorder,
  • Neurologic disease,
  • Psychiatric disorders,
  • Allergic to Local anesthetic drugs,
  • Patients who have received sedatives,analgesics or opioids within the previous 24 hrs.

Treatment and study plan

Lidocaine 1mg/kg

Drug

The total dosage of Etomidate needed for induction of anesthesia is recorded at last.

Other names: Lidocaine, serial number:1303E11, Etomidate-Lipuro, serial number:11215033

Lidocaine 1.5mg/kg

Drug

same as other

Other names: Lidocaine, serial number:1303E11, Etomidate-Lipuro, serial number:11215033

Lidocaine 2mg/kg

Drug

same as other

Other names: Lidocaine, serial number:1303E11, Etomidate-Lipuro, serial number:11215033

Lidocaine 2.5mg/kg

Drug

same as other

Other names: Lidocaine, serial number:1303E11, Etomidate-Lipuro, serial number:11215033

Primary outcomes

  1. changes in blood pressure and heart rate.

    Time frame: 6 weeks

Sponsors and collaborators

Lead sponsor

West China Hospital

Other

Registry information

Official study title

Can Intravenous Lidocaine Decrease the Minimal Inducing Dose of Etomidate?: A Randomized Placebo-controlled Dose-response Study.

Important dates

Study start
2013
Primary completion
2013
Study completion
2013
First posted
Aug 5, 2013
Registry last updated
Aug 5, 2013

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.