A Diagnostic Study of the Advanced Endoscopy to Detect Early Esophageal Cancer

This descriptive cross sectional study aims to directly compare the diagnostic capability of the probed-based confocal laser endomicroscopy (pCLE) and the magnifying narrow band imaging (M-NBI) in the Lugol's voiding lesions.

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Key information

Conditions

Esophageal Neoplasms Digestive System Diseases Digestive System Neoplasms Esophageal Diseases Gastrointestinal Diseases Gastrointestinal Neoplasms Head and Neck Neoplasms Neoplasms Neoplasms by Site

Age range

20 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Age over 20 years
Having histological-confirmed diagnosis of head and neck cancer
Having no esophageal symptoms

Exclusion criteria

Having index cancer of nasopharynx
History of esophageal surgery
Having esophageal stricture or obstruction
Having esophageal varices
Known case of esophageal cancer
Uncorrectable coagulopathy and thrombocytopenia
Pregnancy
Thyrotoxicosis
Creatinine clearance less than 30 ml/min
Allergy to iodine or fluorescein.

Treatment and study plan

Olympus

Device

narrow band imaging with magnification

Cellvizio

Device

probe-based confocal laser endomicroscopy

Primary outcomes

Accuracy

Time frame: an expected average of 2 weeks

Diagnostic performance of the pCLE and M-NBI in Lugol's voiding lesions size larger than 5 millimeters.

Sponsors and collaborators

Lead sponsor

King Chulalongkorn Memorial Hospital

Other

Collaborators

Chulalongkorn University

Registry information

Official study title

Diagnostic Values of Probe-based Confocal Laser Endomicroscopy (pCLE) and Magnifying Narrow Band Imaging (M-NBI) for Early Neoplasms Detection in Esophageal Lugol'S-voiding Lesions.

Important dates

Study start: 2013
Primary completion: 2014
Study completion: 2014
First posted: Jul 8, 2014
Registry last updated: Aug 28, 2020

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed