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OpenTrials
Completed

NCT Number: NCT05689073

A Conversational AI System to Enhance Knowledge About Vaccines and Promote Vaccination

This study is designed to contribute to the growing body of evidence on the efficacy of digital health interventions. By rigorously evaluating the impact of the AI system on vaccine knowledge and acceptance, the study aims to inform future health communication strategies and policies. It stands as a potential model for integrating AI into public health initiatives, showcasing how technology can be harnessed to improve health outcomes on a large scale.

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Key information

Conditions

Vaccination Hesitancy Behavior Health Behavior Treatment Adherence and Compliance Treatment Refusal Vaccination Refusal

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Zhongshan Ophthalmic Center

Guangzhou, Guangdong, 510000, China

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Individuals aged 18 or above
  • Owning a smartphone/tablet capable of using the study app
  • Willing to provide informed consent.

Exclusion criteria

  • Individuals with ocular or hearing disorders that preclude the use of mobile phones or reading.
  • Individuals with mental disorders that preclude the use of mobile phones or reading.

Treatment and study plan

Conversational AI system

Device

The conversational AI system based on LLM processes user queries with a sophisticated generation, decision, action, and safety framework to provide optimal feedback. The system has several key features. Firstly, it utilizes retrieval-augmented in-context learning to enhance responses generated by the LLM, sourcing information from trustworthy websites. Secondly, it includes Guardrail module that addresses potential harmful content in the LLM-generated responses by clarifying and validating the content before delivery. Furthermore, the AI system is equipped with Self-checking memory module that retains essential clinical characteristics across multi-turn dialogues, ensuring the continuity and consistency of its interactions with users. The educational content about vaccination was derived from the official website of World Health Organization (https://www.who.int/news-room/questions-and-answers/item/vaccines-and-immunization-what-is-vaccination).

Printed educational Brochure

Other

A printed brochure whose content about vaccination was derived from the official website of World Health Organization (https://www.who.int/news-room/questions-and-answers/item/vaccines-and-immunization-what-is-vaccination).

Primary outcomes

  1. Acceptance of vaccines

    Time frame: Day 14

    Vaccine acceptance was evaluated based on responses to the question, 'Based on your actual situation, please choose the extent of your willingness to get vaccinated.' The response options were: Absolutely refuse, Refuse but uncertain about the future, Have not considered it yet, Accept but still considering, and Completely willing. Vaccine acceptance was considered if the participant selected 'Completely willing.

Secondary outcomes

  1. Hesitancy of vaccination

    Time frame: Day 14

    The Vaccine Hesitancy Scale was developed based on the "3Cs" model (confidence, complacency, and convenience) by the SAGE Working Group on Vaccine Hesitancy, encompassing three aspects: confidence, complacency, and convenience. It utilizes a Likert 5-point scale (Strongly Disagree, Disagree, Neutral, Agree, Strongly Agree) for scoring. For the complacency dimension, aspect, scoring is reversed with "Strongly Agree" to "Strongly Disagree" rated as 5 to 1 points, respectively. In contrast, other items follow the standard scoring, where "Strongly Agree" to "Strongly Disagree" are scored from 1 to 5 points. Confidence is measured by perceived vaccine safety and efficacy. Complacency is assessed through perceived necessity of the vaccine and the severity of the preventable diseases. Convenience is evaluated by the perceived ease of transportation and appointment scheduling.

Other outcomes

  1. Feelings of coercion

    Time frame: Day 14

    To assess feelings of coercion related to vaccination, participants were asked a single question: 'When deciding whether to receive the vaccines, do you feel forced to either take or not take the vaccine?' This question utilizes a 5-point Likert scale (very low, low, neutral, high, very high) with lower scores indicating lower feelings of perceived coercion.

Sponsors and collaborators

Lead sponsor

Sun Yat-sen University

Other

Registry information

Official study title

A Conversational AI System to Enhance Knowledge About Vaccines and Promote Vaccination: A Randomized Controlled Trial

Important dates

Study start
2023
Primary completion
2023
Study completion
2023
First posted
Jan 18, 2023
Registry last updated
Jan 19, 2024

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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