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Completed

NCT Number: NCT07451717

A Comprehensive Interdisciplinary Assessment of the Impact of Ultramarathons on the Health of Middle-aged and Older Amateur Runners - SUPERMARATON 2025 Project

The "Supermarathon 2025" study was designed as a prospective, interdisciplinary field study to assess the impact of extreme physical exertion, such as a 100-kilometer ultramarathon, on the health of individuals aged ≥ 45 years. A multi-module strategy was employed, including assessment of metabolic, circulatory, respiratory, neurological, dental, psychological, and musculoskeletal functions.

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Key information

Conditions

The Impact of Extreme Physical Exertion on Health The Impact of Extreme Physical Exertion on Cardiovascular System The Impact of Extreme Physical Exertion on Glucose The Impact of Extreme Physical Exertion on Joints and Muscles The Impact of Extreme Physical Exertion on Kidney Function and Water-electrolytes Balance The Impact of Extreme Physical Exertion on Neurological System The Impact of Extreme Physical Exertion on Respiratory System

Age range

44 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Medical University of Gdańsk

Gdansk, Poland

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Age ≥ 45 years
  • Planned completion of a 100 km race during a specific sporting event
  • Willingness to participate in all research procedures included in the project

Exclusion criteria

  • Refusal to participate in the project
  • Occurrence of serious illnesses that may pose a risk to the athlete
  • Detection of significant changes in health status during the initial examination that may be associated with complications during exercise (participants were advised against participating in the race and were not included in the study group)

Treatment and study plan

Blood and urine analysis

Diagnostic Test

Blood and urine analysis

Primary outcomes

  1. Changes in blood and urine results

    Time frame: Blood and urine samples were collected one day before the start and three times after the start - within 1 hour after finishing the race, after 12-15 hours after finishing the race and five days after finishing the race.

    NT-proBNP in pg/ml

  2. Troponin I

    Time frame: Blood and urine samples were collected one day before the start and three times after the start - within 1 hour after finishing the race, after 12-15 hours after finishing the race and five days after finishing the race.

    Troponin I in ng/L

  3. Glucose

    Time frame: Blood and urine samples were collected one day before the start and three times after the start - within 1 hour after finishing the race, after 12-15 hours after finishing the race and five days after finishing the race.

    Glucose in mg/dl

  4. Insulin

    Time frame: Blood and urine samples were collected one day before the start and three times after the start - within 1 hour after finishing the race, after 12-15 hours after finishing the race and five days after finishing the race.

    Insulin in ulU/ml

  5. Hemoglobin A1c

    Time frame: Blood samples were collected one day before the start

    Hemoglobin A1c in %

  6. Lipid profile

    Time frame: Blood samples were collected one day before the start

    LDL cholesterol, HDL cholesterol, total cholesterol and Triglicerydes in mg/dl

  7. Creatinine kinase

    Time frame: Blood and urine samples were collected one day before the start and three times after the start - within 1 hour after finishing the race, after 12-15 hours after finishing the race and five days after finishing the race.

    Creatinine kinase in U/l

  8. Uric acid

    Time frame: Blood and urine samples were collected one day before the start and three times after the start - within 1 hour after finishing the race, after 12-15 hours after finishing the race and five days after finishing the race.

    Uric acid in mg/dl

  9. Vitamine D3

    Time frame: Blood and urine samples were collected one day before the start and three times after the start - within 1 hour after finishing the race, after 12-15 hours after finishing the race and five days after finishing the race.

    Vitamine D3 in ng/ml

  10. Serum iron

    Time frame: Blood and urine samples were collected one day before the start and three times after the start - within 1 hour after finishing the race, after 12-15 hours after finishing the race and five days after finishing the race.

    serum iron in ug/dl

  11. Ferritin

    Time frame: Blood and urine samples were collected one day before the start and three times after the start - within 1 hour after finishing the race, after 12-15 hours after finishing the race and five days after finishing the race.

    Ferritin in ng/ml

  12. Creatinine

    Time frame: Blood and urine samples were collected one day before the start and three times after the start - within 1 hour after finishing the race, after 12-15 hours after finishing the race and five days after finishing the race.

    Creatinine in mg/dl

  13. Sodium

    Time frame: Blood and urine samples were collected one day before the start and three times after the start - within 1 hour after finishing the race, after 12-15 hours after finishing the race and five days after finishing the race.

    Sodium in mmol/l

  14. Potassium

    Time frame: Blood and urine samples were collected one day before the start and three times after the start - within 1 hour after finishing the race, after 12-15 hours after finishing the race and five days after finishing the race.

    Potassium in mmol/l

  15. C-reative protein

    Time frame: Blood and urine samples were collected one day before the start and three times after the start - within 1 hour after finishing the race, after 12-15 hours after finishing the race and five days after finishing the race.

    C-reractive protein in mg/l

  16. Liver enzymes

    Time frame: Blood and urine samples were collected one day before the start and three times after the start - within 1 hour after finishing the race, after 12-15 hours after finishing the race and five days after finishing the race.

    alanine aminotransferase, aspartate aminotransferase in U/L

  17. Bilirubin

    Time frame: Blood and urine samples were collected one day before the start and three times after the start - within 1 hour after finishing the race, after 12-15 hours after finishing the race and five days after finishing the race.

    Bilirubin in mg/dl

  18. Albumin

    Time frame: Blood and urine samples were collected one day before the start and three times after the start - within 1 hour after finishing the race, after 12-15 hours after finishing the race and five days after finishing the race.

    Albumin in g/l

  19. Cortisol in saline

    Time frame: Saline smaples were taken one day before the race and within one hour after finishing the race

    Cortisol in saline in ug/dL

  20. FSH and LH

    Time frame: Blood samples were collected one day before the start and within 1 hour after finishing the race

    FSH and LH

  21. Estradiol

    Time frame: Blood samples were collected one day before the start and within 1 hour after finishing the race

    Estradiol in pg/ml

  22. Testosterone

    Time frame: Blood samples were collected one day before the start and within 1 hour after finishing the race

    Testosterone in ng/dl

  23. SHGB

    Time frame: Blood samples were collected one day before the start and within 1 hour after finishing the race

    SHGB in nmol/l

  24. Cortisole and progestrone

    Time frame: Blood samples were collected one day before the start and within 1 hour after finishing the race

    Cortisole and progestrone in ng/ml

  25. Continuous glucose monitoring

    Time frame: Sensor was placed one day before the race and was measuring glucose for 14 days

    continuous glucose monitoring using FS libre

  26. Weight

    Time frame: Measurements were taken 1 day before and within 1 hour after finishing the race

    Weight in kilograms

  27. Height

    Time frame: Measurements were taken 1 day before the race

    Height in cm

  28. Body composition

    Time frame: Measurements have been made 1 day before the race and within 1 hour after finishing the race

    Body composition using Tanita BC-545N - parameters in %

  29. ECG

    Time frame: Measurements have been made 1 day before the race and within 1 hour after finishing the race

    ECG measurements

  30. Echocardiography

    Time frame: Measurements have been made 1 day before the race and within 1 hour after finishing the race

    Echocardiography

  31. ECG Holter

    Time frame: ECG Holter was connected 1 day before the race and was checking heart rate and ecg within following 14 days

    ECG Holter

  32. Neurological examination

    Time frame: Examination was performed 1 day before the race and within 1 hour after finishing the race

    Neurological examination

  33. Dental examination

    Time frame: Examination was performed 1 day before the race and within 1 hour after finishing the race

    Dental examination

  34. Ortophedic examination

    Time frame: Examination was performed 1 day before the race and within 1 hour after finishing the race

    Ortophedic examination

  35. Spirometry

    Time frame: Examination was performed 1 day before the race and within 1 hour after finishing the race

    Spirometry

  36. Psychological examination

    Time frame: Examination was performed 1 day before the race and within 1 hour after finishing the race

    Psychological examination

Sponsors and collaborators

Lead sponsor

Medical University of Gdansk

Other

Registry information

Important dates

Study start
2025
Primary completion
2025
Study completion
2025
First posted
Mar 5, 2026
Registry last updated
Mar 5, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.