USDA Beltsville Human Nutrition Research Center
Beltsville, Maryland, 20705, United States
NCT Number: NCT01617525
The primary aim of this study is to compare, in a group of at-risk individuals, the role of three dietary patterns on indices of Cardiovascular Disease (CVD) risk: a) the recommended Korean pattern; b) the typical American diet, based on national dietary intake surveys; and c) the 2010 DGA diet pattern. A secondary aim will be to assess the effects of each diet on intestinal microbiota and on inflammatory biomarkers.
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Notify Me25 year–65 year
All sexes
Interventional
Not applicable
Beltsville, Maryland, 20705, United States
Healthy volunteers accepted: Yes
Only the study team can determine whether someone qualifies for participation.
Inclusion criteria
Exclusion criteria
All meals will be provided during each 4-week intervention period. Participants must consume all foods provided and must not consume any outside foods during each intervention period.
Time frame: End of each 4-week diet period
Plasma total cholesterol, HDL and LDL cholesterol, insulin, glucose, and serum triglycerides will be measured.
Time frame: End of each 4-week diet
Cytokine production will be analyzed by selecting representative pro-inflammatory cytokine genes (i.e. TNF-a, IL-12, IL-6, IFNg), anti-inflammatory genes (IL-10), and different signaling pathways (i.e. Mitogen activated protein kinase (MAPK) p38, phosphatidylinositol 3 (PI3) kinase, and nuclear factor Kappa B (NF-KB).
Time frame: End of each 4-week diet
Plasma adiponectin, ghrelin, PYY and leptin will be measured.
Time frame: End of each 4-week diet
Time frame: End of each 4-week diet
Time frame: At baseline and after 4-weeks of each diet
Fecal samples will be collected to study changes in bacterial abundance of commensal microorganisms such as Bifidobacterium spp., Lactobacillus spp., E.coli spp. and Bacteroides fragilis spp.
Time frame: At end of each 4-week diet
Participants will be asked to complete questionnaires regarding acceptability, satiety, and gastrointestinal symptoms.
USDA Beltsville Human Nutrition Research Center
Fed
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