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Completed

NCT Number: NCT05869526

A Comparison of the Effects of Krill Oil and Fish Oil Supplementation on Muscle Function in Older Adults

The aim of the study is to compare the effects of Krill Oil and Fish Oil supplementation on muscle function in older adults. The secondary aim is to investigate the mechanisms underlying the beneficial effects previously observed.

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Key information

Conditions

Sarcopenia Atrophy Muscular Atrophy Nervous System Diseases Neurologic Manifestations Neuromuscular Manifestations Pathological Conditions, Anatomical Pathological Conditions, Signs and Symptoms Signs and Symptoms

Age range

60 year–90 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Stuart Robert Gray

Glasgow, Scotland, United Kingdom

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Older adults (aged 60 years or older). BMI less than 30kg/m2

Exclusion criteria

  • Participants (diagnosed and being treated for a pre-existing medical condition (cancer, kidney disease, liver disease, diabetes mellitus and cardiovascular disease, uncontrolled hypertension, gait disturbances limiting the ability to perform assessments of muscle function, dementia, affecting muscles known to use drugs (e.g., steroids). History of allergy to fish or fish oil and regular consumption of more than1portion of oily fish per week or use of fish oil or krill oil supplements will also be excluded.

Treatment and study plan

Fish Oil

Dietary Supplement

EPA rich fish oil

Kril oil

Dietary Supplement

Superba Krill Oil

Vegetable oil

Dietary Supplement

Mixed vegetable oil

Primary outcomes

  1. Change in knee extensor maximal isometric torque ( MVC)

    Time frame: Change from baseline to 16 weeks

    Knee extensor maximal isometric torque measured during a maximal voluntary contraction

Secondary outcomes

  1. Change in fat mass

    Time frame: Change from baseline to 16 weeks

    Whole body fat mass measured by measured via bio-electrical impedance

  2. Change in lean mass

    Time frame: Change from baseline to 16 weeks

    Whole body lean mass measured by measured via bio-electrical impedance

  3. Blood sample

    Time frame: Change from baseline to 16 weeks

    Red Blood Cell Omega-3 levels

  4. Change in Grip strength

    Time frame: Change from baseline to 16 weeks

    Grip strength measured with a hand held dynamometer

  5. Change in Muscle thickness

    Time frame: Change from baseline to 16 weeks

    Vastus lateralis muscle thickness measured by ultrasound

  6. Force steadiness during submaximal isometric knee extensor contractions

    Time frame: Change from baseline to 16 weeks

    Measured by using intramuscular iEMG

  7. Neuromuscular Junction (NMJ)

    Time frame: Change from baseline to 16 weeks

    Measured by iEMG

  8. Change in gait speed

    Time frame: Change from baseline to 16 weeks

    Time taken to walk 4 metres at a normal walking pace

  9. Change in Chair rise time

    Time frame: Change from baseline to 16 weeks

    A 30-second sit-to-stand test measured functional abilities

Other outcomes

  1. Step Time (Sec)

    Time frame: Change from baseline to 16 weeks

    Measured during a 4m walk using a gaitrite mat

  2. Cycle Time (Sec)

    Time frame: Change from baseline to 16 weeks

    Measured during a 4m walk using a gaitrite mat

  3. Step Length (CM)

    Time frame: Change from baseline to 16 weeks

    Measured during a 4m walk using a gaitrite mat

  4. Stride Length (CM)

    Time frame: Change from baseline to 16 weeks

    Measured during a 4m walk using a gaitrite mat

  5. H-H Base Support (CM)

    Time frame: Change from baseline to 16 weeks

    Measured during a 4m walk using a gaitrite mat

  6. Single Support (%GC)

    Time frame: Change from baseline to 16 weeks

    Measured during a 4m walk using a gaitrite mat

  7. Double Support (%GC)

    Time frame: Change from baseline to 16 weeks

    Measured during a 4m walk using a gaitrite mat

  8. Swing (%GC)

    Time frame: Change from baseline to 16 weeks

    Measured during a 4m walk using a gaitrite mat

  9. Stance (%GC)

    Time frame: Change from baseline to 16 weeks

    Measured during a 4m walk using a gaitrite mat

  10. Step/ Extremity Ratio

    Time frame: Change from baseline to 16 weeks

    Measured during a 4m walk using a gaitrite mat

  11. Toe In/ Out (deg)

    Time frame: Change from baseline to 16 weeks

    Measured during a 4m walk using a gaitrite mat

  12. Distance (CM)

    Time frame: Change from baseline to 16 weeks

    Measured during a 4m walk using a gaitrite mat

  13. Ambulation Time (Sec)

    Time frame: Change from baseline to 16 weeks

    Measured during a 4m walk using a gaitrite mat

  14. Velocity (CM/Sec)

    Time frame: Change from baseline to 16 weeks

    Measured during a 4m walk using a gaitrite mat

  15. Mean Normalized Velocity

    Time frame: Change from baseline to 16 weeks

    Measured during a 4m walk using a gaitrite mat

  16. Number of Steps

    Time frame: Change from baseline to 16 weeks

    Measured during a 4m walk using a gaitrite mat

  17. Cadence (Steps/Min)

    Time frame: Change from baseline to 16 weeks

    Measured during a 4m walk using a gaitrite mat

  18. Step Time Differential (Sec)

    Time frame: Change from baseline to 16 weeks

    Measured during a 4m walk using a gaitrite mat

  19. Step Length Differential (CM)

    Time frame: Change from baseline to 16 weeks

    Measured during a 4m walk using a gaitrite mat

  20. Cycle Time Differential (Sec)

    Time frame: Change from baseline to 16 weeks

    Measured during a 4m walk using a gaitrite mat

Sponsors and collaborators

Lead sponsor

University of Glasgow

Other

Registry information

Official study title

A Comparison of the Effects of Krill Oil and Fish Oil Supplementation on Muscle Function in Older Adults: a Randomised Controlled Pilot Study

Important dates

Study start
2023
Primary completion
2024
Study completion
2024
First posted
May 22, 2023
Registry last updated
Mar 30, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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