: A Comparison of Neuromuscular Transmission in the Muscles During General Anesthesia

In our research in addition to the standard intraoperative monitoring, which includes the assessment of ECG and saturation, the investigators would like to estimate muscle relaxation by using two different methods: a TOF-Cuff which additionally allows to measure inoperative blood pressure and TOF-Scan with different sensor. Our aim is to compare two different methods of muscle relaxation monitoring in patients who will administer muscle relaxant - mivacurium. After receiving painkillers and hypnotics, when the patient is falling asleep, the standard dose of mivacurium 0.2 mg / kg body weight will be administered. Then, painless simultaneous stimulation with TOF-Cuff and TOF-Scan devices will begin. Until intubation, measurements will be made in every 30 seconds and then every 5 minutes until extubation. Extubation will take place according to the guidelines when the TOF-Cuff measurement on the arm is greater than 0.9 - this is the value at which the patient is considered ready to start breathing on his own. The following will be documented: the initiation of drug administration, intubation, possible repeated doses of mivacurium 2 mg, antagonization, extubation, possible side effects (e.g., transient cardiac disturbances, reddening of the skin, lowering blood pressure, bronchospasm, erythema, urticaria) and technical problems.

Inclusion criteria

• Age 18-75
• ASA classification I,II,III
• Elective surgery
• BMI(body mass index) 17-35
• Surgery in the supine position
• Informed consent of the patient

Exclusion criteria

• Pregnancy and breastfeeding
• Urgent indications for surgery
• ASA classification >III
• Neuromuscular diseases
• Polyneuropathy
• Diabetes
• Drug addiction
• Family history of malignant hyperthermia
• Allergic to propofol, fentanyl or mivacurium