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OpenTrials
Completed

NCT Number: NCT02289261

A Comparison of Morphine and Morphine Plus Dexmedetomidine in Chronic Cancer Pain

The purpose of this study is to determine whether dexmedetomidine added to morphine is effective in the treatment of chronic cancer pain.

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Key information

Conditions

Chronic Pain Neurologic Manifestations Pain Pathological Conditions, Signs and Symptoms Signs and Symptoms

Age range

20 year–80 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Phase 4

Primary location

Cukurova University Faculty of Medicine Research Hospital

Adana, 01130, Turkey (Türkiye)

About this study

We conduct the study in Cukurova University Faculty of Medicine Research Hospital after obtaining ethics committee approval and patient's informed consent. Patients with cancer pain are allocated into two group to receive Patient Controlled Analgesia with morphine or morphine plus dexmedetomidine.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • patients with chronic cancer pain
  • between 20-80 years old age

Exclusion criteria

  • the presence of severe systemic disease(cardiac, pulmonary, hepatic or renal)
  • psychiatric or neurologic disease
  • unable to communicate verbally
  • nausea and vomiting
  • patient's refusal

Treatment and study plan

Morphine

Drug

Morphine, 0.02 mg/kg PCA bolus dose with 10 minutes lock-out interval

Other names: morphine sulphate

Morphine plus dexmedetomidine

Drug

Morphine 0.02 mg/kg plus dexmedetomidine 0.1 microgram/kg PCA bolus dose with 10 minutes lock-out interval

Other names: Morphine sulphate plus dexmedetomidine

Primary outcomes

  1. Morphine consumption (mg)

    Time frame: 24 hours

    cumulative morphine consumption for 24 hours

Secondary outcomes

  1. Pain score

    Time frame: 24 hours

    visual analog scale to assess pain degree

Sponsors and collaborators

Lead sponsor

Cukurova University

Other

Registry information

Important dates

Study start
2014
Primary completion
2015
Study completion
2015
First posted
Nov 13, 2014
Registry last updated
Jun 19, 2018

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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