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Completed

NCT Number: NCT03024203

A Comparison of Cognitive Training Approaches in Psychotic Disorders

Cognitive remediation (CR) is the best treatment to improve neurocognitive abilities for individuals with psychosis, however, there is no gold standard method of cognitive remediation available. Cognitive training refers to the training component of CR in which people practice computerized exercises that train specific cognitive abilities. There is no agreed upon approach within the field as to the type of training that is most effective with some studies, training higher level cognitive abilities, some training perceptual abilities, and others training general cognitive skills. This study will directly compare two competing methods of cognitive training on measures of neurophysiology, neurocognition, functional competence, and real-world functional performance.

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Key information

Conditions

Psychotic Disorders Mental Disorders Schizophrenia Spectrum and Other Psychotic Disorders

Age range

18 year–65 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Queen's University

Kingston, Ontario, K7L 5P6, Canada

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • psychotic disorder
  • No previous cognitive remediation in past 6 months

Exclusion criteria

  • Brain injury
  • Substance abuse
  • Neurocognitive disorder
  • Developmental Disability

Treatment and study plan

Cognitive Remediation - Executive Training

Behavioral

Cognitive remediation is a cognitive and behavioural therapy designed to improve cognitive skills such as memory, and problem solving ability.

Cognitive Remediation - Perceptual Training

Behavioral

Cognitive remediation is a cognitive and behavioural therapy designed to improve cognitive skills such as attention, and processing speed.

Primary outcomes

  1. Change in Functional Performance - Specific Levels of Functioning (SLOF) from Baseline

    Time frame: Post-treatment (within 2 weeks following the end of treatment)

    Rating scale completed by participants' case managers that rates their ability to perform different everyday tasks

Secondary outcomes

  1. Change in Neurocognition - MATRICS Cognitive Consensus Battery (MCCB) from Baseline

    Time frame: Post-treatment (within 2 weeks following the end of treatment)

    The MCCB is the gold standard cognitive assessment for schizophrenia research

  2. Change in Neurophysiology - EEG from Baseline

    Time frame: Post-treatment (within 2 weeks following the end of treatment)

    Alpha and Theta band synchronization, p300, mismatch negativity

  3. Functional Competence - Canadian Objective Assessment of Life Skills Brief (COALS-B) from Baseline

    Time frame: Post-treatment (within 2 weeks following the end of treatment)

    Performance based measure of real life functional skills using role-play

  4. Change in Functional Performance - Specific Levels of Functioning (SLOF) from Baseline

    Time frame: Follow-Up (3 months after the end of treatment)

    Rating scale completed by participants' case managers that rates their ability to perform different everyday tasks

  5. Change in Neurocognition - MATRICS Cognitive Consensus Battery (MCCB) from Baseline

    Time frame: Follow-Up (3 months after the end of treatment)

    The MCCB is the gold standard cognitive assessment for schizophrenia research

  6. Change in Neurophysiology - EEG from Baseline

    Time frame: Follow-Up (3 months after the end of treatment)

    Alpha and Theta band synchronization, p300, mismatch negativity

  7. Functional Competence - Canadian Objective Assessment of Life Skills Brief (COALS-B) from Baseline

    Time frame: Follow-Up (3 months after the end of treatment)

    Performance based measure of real life functional skills using role-play

Sponsors and collaborators

Lead sponsor

Queen's University

Other

Registry information

Important dates

Study start
2016
Primary completion
2018
Study completion
2018
First posted
Jan 18, 2017
Registry last updated
Nov 14, 2018

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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