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Completed

NCT Number: NCT00607815

A Comparison of Cognitive Processing Therapy (CPT) Versus Present Centered Therapy (PCT) for Veterans

The purpose of this study is to compare the effectiveness of Cognitive Processing Therapy (CPT) versus Present Centered Therapy (PCT) for male OEF/OIF Veterans with combat related PTSD.

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Key information

Age range

18 year–75 year

Sex eligibility

Male

Study type

Interventional

Phase

Not applicable

Primary location

Cincinnati VA Medical Center, Cincinnati, OH

Cincinnati, Ohio, 45220, United States

About this study

The purpose of this study is to compare the effectiveness of Cognitive Processing Therapy (CPT) versus Present Centered Therapy (PCT) for male OEF/OIF Veterans with combat related PTSD.

CPT has been shown to be effective in treating trauma survivors in several treatment outcome studies, but utility with Veterans has only been examined with male Veterans in one small pilot study. In addition CPT has never been compared to a treatment as usual or supportive psychotherapy condition to control for the specific and nonspecific elements of treatment. Although Cognitive Processing Therapy is one of the main treatment modalities at several VA's, including Cincinnati, it has never been compared to PCT, nor has it been used in a large, randomized study of male OEF/OIF Veterans. It is hypothesized that individual receiving CPT will show a larger reduction in posttraumatic stress disorder and related symptoms than those individuals receiving PCT.

All male OEF/OIF Veterans will be screened for their appropriateness for the study by phone screen and then by an assessment technician. The Veteran will be assessed at pre, post, 3-month, and 1-year follow-up. The assessment technicians will be blind to the participant's condition. CPT is a 12 week long individual psychotherapy treatment shown to be effective at reducing PTSD and related symptoms for survivors of various types of traumas, including combat. PCT is a supportive counseling treatment that has been utilized as an alternative to waitlist control in VA cooperative studies of PTSD.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • PTSD;
  • memory of the trauma;
  • able to read/write;
  • must be stable on medication for 3 months

Exclusion criteria

  • Psychosis;
  • suicidal/homicidal intent;
  • alcohol/substance dependence;
  • no memory of the trauma

Treatment and study plan

cognitive processing therapy

Behavioral

CPT is a highly structured protocol in which the client learns the skill of recognizing and challenging dysfunctional cognitions, first about the worst traumatic event and then later with regard to the meaning of the events for current beliefs about self and others.

Present Centered Therapy

Behavioral

Present centered therapy is a supportive counseling model developed by Drs. Foa and Shea. The treatment is called "present centered therapy" to 1) emphasize the need to focus on the participant's current life and 2) to conceptualize the problems as being caused by PTSD, and in some cases they may have been present for a long period of time. The treatment makes a connection between PTSD and current problems thus making it a more realistic PTSD treatment and still allowing PCT to control for nonspecific therapeutic factors

Primary outcomes

  1. Clinician Administered PTSD Scale

    Time frame: Post-treatment, at 3 months and 1 year

    Clinician-rated PTSD symptom severity; higher is worse; range at post-treatment is 0 to 80; scale scores are summed.

  2. PTSD Checklist (PCL)

    Time frame: post-treatment, at 3 months and 1 year

    17-item patient self-reported PTSD severity; higher is worse; range at post-treatment is 17-73; scale scores are summed

Secondary outcomes

  1. Beck Depression Inventory - II (BDI-II)

    Time frame: post-treatment, at 3 months and 1 year

    Gold-standard, self-reported depression severity measure; higher is worse; post-treatment range is 2-45. scale scores are summed.

  2. State-Trait Anger Scale (STAXI)

    Time frame: post-treatment, at 3 months and 1 year

    Self-reported trait anger; subscale score is summed; higher is worse; range at post-treatment is 10-37.

  3. State-Trait Anxiety Scale

    Time frame: post-treatment, at 3 months and 1 year

    Self-reported state anxiety; higher is worse; scale score is summed; range at post-treatment is 20-73.

Sponsors and collaborators

Lead sponsor

VA Office of Research and Development

Fed

Registry information

Official study title

A Comparison of CPT vs PCT for Veterans

Important dates

Study start
2009
Primary completion
2015
Study completion
2015
First posted
Feb 6, 2008
Registry last updated
Jun 26, 2018

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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