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Completed

NCT Number: NCT01950793

A Comparison Between Sonoguided Injection Corticosteroid and Hyaluronic Acid Injection in Treatment of Trigger Finger

The study is to compare the effect between steroid injection and Hyaluronic acid in treatment trigger finger. Using sonoguided injection technique achieves more accurate injection location and therapeutic effect. We hypothesize hyaluronic acid has both lubricant and anti-inflammation effect in treatment of trigger finger, and can provide better outcome and lower adverse effect than steroid injection.

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Key information

Conditions

Trigger Finger Muscular Diseases Musculoskeletal Diseases Tendinopathy Tendon Entrapment Trigger Finger Disorder

Age range

20 year–65 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Taipei Veterans General Hospital

Taipei, Taiwan

About this study

This is a prospective, randomized, double-blinded controlled study. Patients with the diagnosis of trigger finger will be recruited and enrolled from Taipei Veteran General Hospital PM&R outpatient clinic. Subjects will be randomized into two groups; hyaluronic acid and triamcinolone acetonide injections, both via ultrasound-guided with one injection only.We hypothesize that through the anti-inflammatory property of the hyaluronate acid, the treatment effects will be as effective as the traditionally used steroid injections with equal or even lower recurrence rate for treatment of trigger finger. We expect that injections of hyaluronate into tendon sheath could become a new treatment option for trigger finger.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • patients with trigger digits and patients
  • without previous treatment of the trigger digit

Exclusion criteria

  • patients with prior treatment of the trigger digit (eg, splinting, injection, or therapy),
  • patients less than
  • 20 years old,
  • patients with allergy or contraindication to hyaluronic acid,
  • patients with trigger digits due to rheumatoid arthritis,
  • and patients with infection at the site of injection.

Treatment and study plan

Triamcinolone Acetonide

Drug

used ultrasound-guided inject 1c.c triamcinolone acetonide 10mg/mL (Shincort®, YSP, Taiwan)into the sheath of the flexor tendons, penetrated to the A1 pulley.

One injection only Steroid

Other names: triamcinolone acetonide 10mg/mL (Shincort®, YSP, Taiwan)

Hyaluronic acid

Drug

used ultrasound-guided inject 1c.c Hyaluronic acid (Artz®, Seikagaku, Japan)into the sheath of the flexor tendons, penetrated to the A1 pulley.

One injection only

Other names: Hyaluronic acid (Artz®, Seikagaku, Japan)

Primary outcomes

  1. Quinnell classification

    Time frame: Pre-injection; 3-weeks and 3-months post-injections

    he Quinnell system grades trigger fingers as:

    0 - normal movement

    • - uneven movement
    • - locking can be corrected with active motion
    • - locking corrected with passive motion
    • - unable to correct deformity

Secondary outcomes

  1. hand functional evaluation

    Time frame: Pre-injection; 3-weeks and 3-months post-injections

    using the Michigan Hand Outcome Questionnaire (MHQ)

  2. visual analog scale

    Time frame: Pre-injection; 3-weeks and 3-months post-injections

  3. total active motion (TAM)

    Time frame: Pre-injection; 3-weeks and 3-months post-injections

    Defi ned as the total ROM achieved when all three joints-metacarpophalangeal (MCP), proximal interphalangeal (PIP) and distal interphalangeal (DIP) of a digit are actively fl exed or extended simultaneously, minus any extension defi cit at any of the three joints

  4. grip strength

    Time frame: Pre-injection; 3-weeks and 3-months post-injections

    dynamometer strength test (JAMAR grip)

Sponsors and collaborators

Lead sponsor

Taipei Veterans General Hospital, Taiwan

Other Gov

Registry information

Official study title

Steroid Versus Hyaluronic Acid Ultrasound-guided Injection for Trigger Finger: A Comparative Study of Outcomes

Important dates

Study start
2012
Primary completion
2014
Study completion
2014
First posted
Sep 25, 2013
Registry last updated
Nov 4, 2014

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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