A Comparative Analysis of Preoperative Liver Volumetry in Living Donor Liver Transplantation

Accurate preoperative graft volume assessment is crucial for successful living donor liver transplantation (LDLT). Although manual and automated computed tomography (CT) volume measurement methods using various volumetric tools are widely used, their accuracy remains uncertain. This study aimed to determine the optimal dry weight correction factor for each method to enhance the prediction of actual graft weight (AGW) and compare the accuracy of different methods.

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Key information

Conditions

Living Donor Liver Transplantation Digestive System Diseases Hepatic Insufficiency Liver Diseases Liver Failure

Sex eligibility

All sexes

Study type

Observational

Primary location

Chungnam National University Hospital

Daejeon, South Korea

About this study

This study is a retrospective diagnostic accuracy study comparing three liver volumetry methods using preoperative donor CT scans in LDLT.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Patients who underwent hepatectomy for living donor liver transplantation performed by the Department of Surgery at Chungnam National University Hospital under the supervision of the principal investigator.

Exclusion criteria

Patients deemed unsuitable for participation in this clinical study by the investigator.

Treatment and study plan

Primary outcomes

Accuracy of preoperative estimated graft volume (EGV) compared to actual graft weight (AGW)

Time frame: From preoperative CT scan (1-2 months before transplantation) to intraoperative measurement (day of transplantation)

The accuracy of preoperative donor CT liver volumetry will be assessed by comparing estimated graft volume (EGV) obtained from three methods (automated, semi-automated, manual) with the actual graft weight (AGW) measured intraoperatively. The error ratio between EGV and AGW will be calculated for each method.

Secondary outcomes

Determination of the optimal dry weight correction factor for each volumetry method

Time frame: From preoperative CT scan (1-2 months before transplantation) to intraoperative measurement (day of transplantation)

The study aims to determine the optimal dry weight correction factor by minimizing the discrepancy between EGV and AGW.

Sponsors and collaborators

Lead sponsor

Chungnam National University Hospital

Other

Registry information

Official study title

Optimizing Accuracy: a Comparative Analysis of Preoperative Liver Volumetry in Living Donor Liver Transplantation from a Surgeon's Perspective

Important dates

Study start: 2011
Primary completion: 2024
Study completion: 2025
First posted: Mar 10, 2025
Registry last updated: Mar 10, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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